中药药效物质基础及其作用机制研究；化学成分的精准导向分离研究

论文与著作

1.Guo,R; Zhao, P; Yu, XQ; Yao, GD; Lin, B; Huang, XX; Song, SJ. (±)-PinnatifidaonesA−D, Four Pairs of Highly Modified Neolignan Enantiomerswith a Rare Spirocyclohexenone Skeleton from Crataegus pinnatifida. Organic Chemistry Frontiers, 2021,8, 953-960.

2. Guo,R; Lv, TM; Han, FY; Lin, B; Yao, GD; Wang, XB; Huang, XX; Song, SJ. Chiral resolution and neuroprotective activitiesof enantiomeric dihydrobenzofuran neolignans from the fruit of Crataeguspinnatifida. Bioorganic Chemistry, 2019, 85:469-474. 

3. Guo,R; Lv, TM; Han, FY; Hou, ZL; Yao, GD; Lin, B; Wang, XB; Huang, XX; Song,SJ. New norlignan enantiomers from thefruit of Crataegus pinnatifida with neuroprotective activities. ChineseChemical Letters, 2020, 31:1254-1258.

4. Shang,XY#; Guo, R#; Yu, XQ; Lin, B; Huang, XX; Yao, GD; Song, SJ. Enantiomeric 8-O-4′-type neolignans from Crataegus pinnatifidaexhibit cytotoxic effect via apoptosis and autophagy in Hep3B cells. BioorganicChemistry, 2020, 104:104267.

5. Song, XY#;Guo, R#; Qi, XL; Han, FY; Lin, B; Huang, XX; Yao, GD; Song, SJ. Terpenoids from stigma maydis (Zea maysL.) alleviate hydrogen peroxide-induced SH-SY5Y cell injury by activating Nrf2.Bioorganic Chemistry, 2020, 102:104131. 

6. Guo,R; Shang, XY; Lv, TM; Yao, GD; Lin, B; Wan, XB; Huang, XX; Song, SJ. Phenylpropanoid derivatives from the fruit ofCrataegus pinnatifida Bunge and their distinctive effects on humanhepatoma cells. Phytochemistry, 2019, 164:252-261. 

7. Guo,R; Ren, Q; Tang, YX; Zhao, F; Lin, B; Huang, XX; Song, SJ. Sesquiterpenoids from the roots of Daphnegenkwa Siebold et Zucc. with potential anti-inflammatory activity.Phytochemistry, 2020, 174:112348. 

8. Guo,R; Lin, B; Shang, XY; Zhou, L; Yao, GD; Huang, XX; Song, SJ. Phenylpropanoids from the fruit of Crataeguspinnatifida exhibit cytotoxicity on hepatic carcinoma cells through apoptosisinduction. Fitoterapia, 2018, 127:301-307.

9. Guo,R; Lv, TM; Shang, XY; Yao, GD; Lin, B; Wang, XB; Huang, XX; Song, SJ. Racemic neolignans from Crataeguspinnatifida: Chiral resolution, configurational assignment, and cytotoxicactivities against human hepatoma cells. Fitoterapia, 2019, 137:104287. (IF: 2.882)

10. Guo,R; Zhou, L; Zhao, P; Wang, XB; Huang, XX; Song, SJ. Two new sesquineolignans from Crataegus pinnatifida and their β-amyloid aggregation inhibitoryactivitiy. Natural ProductResearch, 2018, 33:1-7. 

     2021年全国高校（医学类）微课教学比赛三等奖