研究领域

心血管药理学

论文与著作

[1] Man Wu R,Wang CY, Wang J, Xu XL(许晓乐). Promotingreverse cholesterol transport contributes to the amelioration ofatherosclerosis by paeoniflorin. Eur J Pharmacol. 2023 Dec15;961:176137.

[2] Wang J, WuR, Hua Y, Ling S, Xu X(许晓乐). Naringeninameliorates vascular senescence and atherosclerosis involving SIRT1 activation.JPharm Pharmacol. 2023 Aug 1;75(8):1021-1033.

[3] Wang CY,Wang J, Cao J, Xu J, Wu RM, Xu XL (许晓乐). ActivatingPGC-1alpha-mediated signaling cascades in the aorta contributes to theamelioration of vascular senescence and atherosclerosis by2,3,4',5-tetrahydroxystilbene-2-O-beta-d-glycoside. Phytomedicine. 2022May;99:154017.

[4] Zeng Y, Cao J, Li CX, Wang CY, Wu RM, Xu XL （许晓乐）. MDM2-Mediated Ubiquitination of RXRbeta Contributes to MitochondrialDamage and Related Inflammation in Atherosclerosis. Int J Mol Sci. 2022 May21;23(10):5766.

[5] Hua YQ, Zeng Y, Xu J, Xu XL （许晓乐）. Naringeninalleviates nonalcoholic steatohepatitis in middle-aged Apoe(-/-)mice: role ofSIRT1. Phytomedicine. 2021 Jan;81:153412.

[6] Zeng Y, Yan Wang C, Xu J, Le XuX (许晓乐). Overexpressionof retinoid X receptor beta provides protection against oxidized low-densitylipoprotein-induced inflammation via regulating PGC1alpha-dependentmitochondrial homeostasis in endothelial cells. Biochem Pharmacol. 2021Jun;188:114559.

[7] Zeng Y, Hua YQ, Wang W, Zhang H,Xu XL （许晓乐）. Modulation of SIRT1-mediated signaling cascades in the liver contributesto the amelioration of nonalcoholic steatohepatitis in high fat fed middle-agedLDL receptor knockout mice by dihydromyricetin. Biochem Pharmacol. 2020May;175:113927.

[8] Zeng Y, Xu J, Hua YQ, Peng Y, XuXL（许晓乐）. MDM2 contributes to oxidized low-density lipoprotein-induced inflammationthrough modulation of mitochondrial damage in endothelial cells. Atherosclerosis.2020 Jul;305:1-9.

[9] Xu J, Peng Y, Zeng Y, Hua YQ, XuXL （许晓乐）. 2, 3, 4', 5-tetrahydroxystilbene-2-0-beta-d Glycoside Attenuates Age- andDiet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDLReceptor Knockout Mice and Its Possible Mechanisms. Int J Mol Sci. 2019 Apr1;20(7):1617.

[10] Peng Y, Xu J, Zeng Y, Chen L, XuXL （许晓乐）. Polydatin attenuates atherosclerosis in apolipoprotein E-deficient mice:Role of reverse cholesterol transport. Phytomedicine. 2019 Sep;62:152935.

[11] Tang K, Wang F, Zeng Y, Chen X, XuX (许晓乐). Salusin-alphaattenuates hepatic steatosis and atherosclerosis in high fat diet-fed lowdensity lipoprotein receptor deficient mice. Eur J Pharmacol. 2018 Jul5;830:76-86.

[12] Zeng Y, Peng Y, Tang K, Wang YQ, Zhao ZY, Wei XY, Xu XL （许晓乐）. Dihydromyricetin ameliorates foam cell formation viaLXRα-ABCA1/ABCG1-dependent cholesterol efflux in macrophages. BiomedPharmacother. 2018 May:101:543-552.

[13] Chen X, Tang K, Peng Y, Xu X（许晓乐）. 2,3,4',5-tetrahydroxystilbene

-2-O-beta-d-glycoside attenuates atherosclerosis in apolipoproteinE-deficient mice: role of reverse cholesterol transport. Can J Physiol Pharmacol.2018 Jan;96(1):8-17.

[14]Liu TT, Zeng Y, Tang K, Chen X, Zhang W, Xu XL （许晓乐）. Dihydromyricetin ameliorates atherosclerosisin LDL receptor deficient mice. Atherosclerosis. 2017 Jul;262:39-50.

荣誉与奖励

作为药理系系副主任，领导药理系各项工作有序开展，更深入地开展了药理教研教改工作，改革并优化了课堂教学过程，提高了课堂教学效率和效果，在南通大学2014-2016年度优秀系（室）评选中本人所带领的药理系获特色系室奖。本人以第一作者发表教学文章3篇；以副主编身份参编《pharmacology》全英文教材一书（江苏大学出版社，ISBN 978-7-5684-0163-0）；参编《药理学应试实训题解》一书（苏州大学出版社，ISBN 978-7-5672-0782-0）；本人获2014年度南通大学优秀教学质量奖；获2015年度“南通大学优秀教育工作者”荣誉称号；获2015年南通大学研究生就业工作先进个人；获2016年度“南通大学第二批团青活力导师”称号；2016年作为唯一导师指导本科生获得获得国家级创新工程项目一项（No. 201610304040Z）。