研究领域

中药药理学（中药复方及其活性成分抗结肠炎/癌及肝纤维化的效应与机制研究）

论文与著作

1. Weiling Lin^#, Bangjie Gu^#, Yuayuan Gu^#, Rui Zhao, Yumeng Huang, Rui Fan, Weihao Rong^*,Zhaoguo Liu^*. Taraxasterol protects against acetaminophen-induced hepatotoxicity by reducing liver inflammatory response and ameliorating oxidative stress in mice [J].International Immunopharmacology, 2024, 138: 112580.

2. Zirong Deng^#, Yun Xu^#, Yuchen Cai, Weiling Lin, Libei Zhang, Aoqing Jiang, Yuhang Zhou, Rui Zhao, Heyan Zhao,Zhaoguo Liu^* and Tingdong Yan^*. Inhibition of ribosomal RNA Processing 15 homolog (RRP15) suppressed tumor growth, invasion and epithelial to mesen-chymal transition (EMT) of colon cancer [J].International Journal of Molecular Sciences, 2023, 24(4): 3528.

3. Libei Zhang^#, Weiling Lin^#, Yunqing Cai^#, Ziyou Huang, Rui Zhao, Tingdong Yan, HongtaoXu^*,Zhaoguo Liu^*. Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice [J].International Immunopharmacology, 2023, 123:110768.

4. Jue Wang^#, Kang Ding^#, Yuhang Wang^#, Tingdong Yan, Yun Xu, Zirong Deng, Weiling Lin, Libei Zhang, Weizhong Zhu, Rui Zhao, Yuhang Zhou,Zhaoguo Liu^*. Wumei Pill ameliorates AOM/DSS-induced colitis-associated colon cancer through inhibition of inflammation and oxidative stress by regulating S-adenosylhomocysteine hydrolase- (AHCY-) mediated hedgehog signaling in mice [J].Oxidative Medicine and Cellular Longevity, 2022, 2022:4061713.

5.Zhaoguo Liu^#, Mengjue Tu^#, Jiannan Shi^#, Hong Zhou, Guoliang Meng, Jianguo Gu^*, Yuqin Wang^*. Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects [J].Frontiers in Pharmacology, 2022, 13:939317.

6. Chang Chen^#, Jingya Gu^#, Jue Wang^#, Yu Wu, Aihua yang, Tingting Chen, Tingting Zhou,Zhaoguo Liu^*. Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression [J].International Immunopharmacology, 2021, 90: 107206.

7. Yuqin Wang^#, Chunling Li^#, Jingya Gu^#, Chang Chen, Jiaxin Duanmu, Jing Miao, Wenjuan Yao, Jinhua Tao, Mengjue Tu, Biao Xiong, Lingling Zhao^*,Zhaoguo Liu^*. Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signaling [J].Journal of Cellular and Molecular Medicine, 2020, 24 (1): 941-953.

8. Jingya Gu^#, Chang Chen^#, Jue Wang^#, Tingting Chen, Wenjuan Yao, Tingdong Yan^*,Zhaoguo Liu^*. Withaferin A exerts preventive effect on liver fibrosis through oxidative stress inhibition in a sirtuin 3-dependent manner [J].Oxidative Medicine and Cellular Longevity, 2020, 2020: 2452848.

9. Jinlin Zhang, Aihua Yang, Yu Wu, Wei Guan, Biao Xiong, Xiaoqing Peng, Xiaojin Wei, Chang Chen,Zhaoguo Liu^*. Stachydrine ameliorates carbon tetrachloride- induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats [J].Biomedicine & Pharmacotherapy, 2018, 97: 1586-1594.

10.Zhaoguo Liu^#,*, Pingting Zhu^#, Lin Zhang, Biao Xiong, Jinhua Tao, Wei Guan, Chunling Li, Chang Chen, Jingya Gu, Jiaxin Duanmu, Wei Zhang^*. Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis [J].Biomedicine & Pharmacotherapy, 2018, 103:1262-1271.

11. Lin Zhang^#, Chang Chen^#, Jiaxin Duanmu, Yan Wu, Jinhua Tao, Aihua Yang, Xiaoqin Yin, Biao Xiong, Jingya Gu, Chunling Li,Zhaoguo Liu^*. Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1α nuclear translocation [J].International Immunopharmacology, 2018, 65: 429-437.

12. Pingting Zhu^#, Yu Wu^#, Aihua Yang, Xingsheng Fu, Ming Mao,Zhaoguo Liu^*. Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis [J].Biomedicine & Pharmacotherapy, 2017, 95:68-76.

荣誉与奖励

1、南通市首届十佳中药年度人物（2022）

2、南通大学第十二届青年教师讲课竞赛一等奖（2021）

3、南通大学优秀教育工作者（2021）