研究领域

免疫药理学，中药药理学，消化系统疾病机制及治疗研究

论文与著作

1.  Xu L, Jiang Y, Xu F, Liu J, Jiang Y, Fang F, Luo L*. Deucravacitinib and shikonin combination therapy ameliorates imiquimod-induced psoriasis in mice. Int J Immunopathol Pharmacol. 2024 March;38:3946320241260262.

2. Feng Y, Wang J, Liu J, Zhou Y, Jiang Y, Zhou W, Wu F, Liu X, Luo L*.Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice. Cells. 2024 Jun 6;13(11):988.

3. Luo L, Leavenworth JW. Analysis of the In Vivo Function of Follicular Regulatory T (TFR) Cells in the Regulation of Antibody Response. Methods Mol Biol. 2023;2559:3-13.

4. Xiaoyan Ren#, Gaoshan Zhang#, Xiang Ling, Linhua Zhang, Yangyang Tian, Guoxiang Zhu, Pengbo Wang, Jianmei W. Leavenworth, Lin Luo*, Fengzhi Li*. Allyl-isothiocyanate Against Colorectal Cancer via the Mutual Dependent Regulation of p21 and Nrf2. European Journal of Pharmacology. 2023, 957, 176016.

5. Liuliu Mao; Jun Chen; Kang Cheng; Zhihua Dou; Jonathan D. Leavenworth; Hengyue Yang; Diyuan Xu; Lin Luo*. Nrf2-Dependent Protective Effect of Paeoniflorin on α-Naphthalene Isothiocyanate-Induced Hepatic Injury, American Journal of Chinese Medicine, 2022, 5(05): 1331-1348.

6. Michael L. Dixon; Lin Luo; Sadashib Ghosh; Jefrey M. Grimes; Jonathan D. Leavenworth and Jianmei W. Leavenworth. Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade. Molecular Cancer,2021,20:150.

7. Zhang Z#, Luo Lin#, Xing C, Chen Y, Xu P, Li M, Zeng L, Li C, Ghosh S, Della Manna D, Townes T, Britt WJ, Wajapeyee N, Sleckman BP, Chong Z, Leavenworth JW, Yang ES. RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4 + T-cell-dependent antitumor immunity. Nature Cancer, 2021, 2(10):1018-1038.

8. Luo Lin; Hu Xianzhen; Michael Dixon; Brandon J. Pope; Jonathan D. Leavenworth; Chander Raman; William R. Meador; Jianmei W. Leavenworth. Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis, Journal of Neuroinflammation, 2021, 18(27): 1-15.

9. Erxia Shen#, Hardis Rabe#, Lin Luo#, Lei Wang, Qin Wang, Jie Yin, Xueying Yang, Wenquan Liu, Jessic M. Sido, Hidetoshi Nakagawa, Lin Ao, Hye-Jung Kim, Harvey Cantor, Jianmei W. Leavenworth. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1  Transcription Factor. Cell Reports. 2019, 29(7): 1848–1861.

10. Lin Luo* ; Gaoshan Zhang ; Liuliu Mao ; Pengbo Wang; Chenghao Xi; Gaoyong Shi; Jianmei W. Leavenworth*. Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway, Toxicology and Applied Pharmacology, 2020, 395(15): 114978.

11. Luo Lin ; Chen Yeru ; Wang Hongyan ; Wang Shengcun; Liu Kaihua; Li Xin; Wang Xiu Jun ; Tang Xiuwen. Mkp-1 protects mice against toxin-induced liver damage by promoting the Nrf2 cytoprotective response , Free Radical Biology and Medicine, 2018, 115: 361-370.

12. Pengbo Wang#; Lin Luo#; Qiusheng Shen; Gaoyong Shi; Anaz Mohammeda; Songshi Ni; Xiang Wu. Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF-β/ smads pathways in rat heart. European Journal of Pharmacology, 2018, 820: 173–182.

13. Lin Luo; Chenghao Xi; Tingting Xu; Gaoshan Zhang; E Qun; Wei Zhang. Muscarinic receptor mediated signaling pathways in hepatocytes from CCL4 -induced liver fibrotic rat, European Journal of Pharmacology, 2017, 807:109-116.

14. Lin Luo; Tingting Xu; Pengbo Wang; Liuliu Mao; Chenghao Xi; Jinhua Huang; Wei Zhang. Expression of muscarinic acetylcholine receptors in hepatocytes from rat fibrotic liver. Experimental and Toxicologic Pathology. 2017, 69: 73–81.

15. Syed Minhaj Uddin Ahmed#; Lin Luo#; Akhileshwar Namani; Xiu Jun Wang; Xiuwen Tang. Nrf2 signaling pathway: Pivotal roles in inflammation. Biochimica et Biophysica Acta. 2017, 1863: 585–597.

16. Lin Luo; Yeru Chen; Deqi Wu; Jiafeng Shou; Shengcun Wang; Jie Ye; Xiuwen Tang ; XiuJun Wang. Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice, Toxicology and Applied Pharmacology, 2015, 288(3): 339-348.

17. Lin Luo, Zhou Ailing. Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury. Journal of  Gastroenterology and Hepatology. 2009, 24(6):1070-6.

荣誉与奖励

1.赤芍治疗黄疸型肝炎有效部位筛选及提取工艺研究，南通市科技进步三等奖，2010.10.30，排名第一。

2.五味子中木脂素类成分分析及血清药化学研究，南通市科技进步三等奖，2015.12.01，排名第二。

3.血清药理学与血清药化学相结合研究中药复方药效物质基础，江苏省中医药科技进步奖，三等奖，2011.10.30，排名第四。