研究领域

神经退行性疾病（帕金森病和阿尔茨海默病）的病理机制和药物靶点开发研究。

论文与著作

1.      Chu, D., Lei L., Gu S., Liu, F., Wu, F.^*. (2024). Dual-specificity tyrosine phosphorylation-regulated kinase 1A promotes the inclusion of amyloid precursor protein exon 7, Biochem Pharmacol, 23:116233

2.      Chu, D., Yang, X., Wang, J., Zhou, Y., Gu, J. H., Miao, J., Wu, F.^*, Liu, F.^*. (2024). Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review. Neural Regen Res, 19(6):1221-1232.

3.      Zhou, W., Yang, X., Wang, H., Yao, W., Chu, D.^*, Wu, F.^*. (2023). Neuronal aerobic glycolysis exacerbates synapse loss in aging mice, Exp Neurol, 371:114590.

4.      Ge, J., Lin, H., Yang, J., Li, Q., Zhou, J., Qin, Z., Wu, F.^*. (2021). TP53-induced glycolysis and apoptosis regulator (TIGAR) ameliorates lysosomal damage in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-mediated mouse model of Parkinson's disease. Toxicol Lett, 339, 60-69.

5.      Ding, W., Lin, H., Hong, X., Ji, D., Wu, F.^*. (2020). Poloxamer 188-mediated anti-inflammatory effect rescues cognitive deficits in paraquat and maneb-induced mouse model of Parkinson's disease. Toxicology, 436, 152437.

6.      Dong, H., Qin, Y., Huang, Y., Ji, D., Wu, F.^*. (2019). Poloxamer 188 rescues MPTP-induced lysosomal membrane integrity impairment in cellular and mouse models of Parkinson's disease. Neurochem Int, 126, 178-186.

7.      Zhang, Y., Wu, F., Iqbal, K., Gong, C. X., Hu, W., Liu, F.^*. (2019). Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice. Sci Rep, 9, 3789.

8.      Gu, J., Wu, F., Xu, W., Shi, J., Hu, W., Jin, N., Qian, W., Wang, X., Iqbal, K., Gong, C. X., Liu, F.^*. (2017). TDP-43 suppresses tau expression via promoting its mRNA instability. Nucleic Acids Res, 45, 6177-6193.

9.      Hu, W., Wu, F., Zhang, Y., Gong, C. X., Iqbal, K., Liu, F.^*. (2017). Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis, Front Aging Neurosci, 27:9:311.

10.    Wu, F., Xu, H. D., Guan, J. J., Hou, Y. S., Gu, J. H., Zhen, X. C., Qin, Z. H.^*. (2015). Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease. Neuroscience, 284, 900-911.

11.    Wu, F., Wang, Z., Gu, J. H., Ge, J. B., Liang, Z. Q., Qin, Z. H.^*. (2013). p38(MAPK)/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson's disease. Neurochem Int, 63, 133-140.

荣誉与奖励

1、  大学生创新训练计划项目（国家级），TXNIP引发星形胶质细胞糖酵解障碍在阿尔茨海默病中机制探讨，起止时间：2023.05-2025.05，指导老师。