研究领域

主要围绕生物医药、发酵功能制品与营养健康工程学科等交叉方向，工程化理念建立完善生物健康工程理论与技术体系，以生物医药精准医疗、绿色生物制造、大健康产品及品质提升等为切入点，开展合成生物学底盘细胞设计、发酵智能调控、干细胞培养、临床医学转化等产业链关键共性技术研究，主要研究方向如下：

（1） 药用功能性聚合物生物合成机理解析与代谢科学

开展聚苹果酸、岩藻多糖、丁二酸酯等生物合成底盘设计、代谢工程改造等改造及新路线合成创制研究。

（2）生化健康产品合成细胞工程化设计与发酵智能调控

开展酶催化合成麦角硫因、NAD、岩藻寡糖等高值产品酶定向进化、细胞合成生物学改造及发酵开关智能化设计等研究

（3）人体合成微生物组学与临床医学转化应用

开展人体生殖道微生物组学生态、免疫治疗、HPV病毒靶向清除、菌群互作以及菌群编辑等，开发微生态制剂及靶向治疗产品。

论文与著作

10. Xiang Zou*,Shanshan Li, Pan Wang, Bingxin Li, Yingying Feng, Shang-tian Yang. Sustainable productionand biomedical application of polymalic acid from renewable biomass and foodprocessing wastes, Critical Review in Biotechnology, 2021,41: 216-218.(IF 8.108)

9. Shanshan Li#, Haiqin Xia#, Aiqing Xie, Zhenyu Wang, Kaijian Ling,Qixiong Zhang, Xiang Zou* Structure of a fucose-rich polysaccharide hydrolyzedfrom EPS produced by Kosakonia sp. CCTCC M2018092 and its application inantibacterial film，International Journal of BiologicalMacromolecules, 2020, 159:295-303. (IF 5.162)

8.Xiaodan Song#, Yongkang Wang#, Tianfu Li, Yongjun Zhang, Xiang Zou*. GATA-typetranscriptional factor Gat1 regulates nitrogen uptake and polymalic acidbiosynthesis in poly1extremetolerant fungus Aureobasidiumpullulans. EnvironmentalMicrobiology, 2020,22（1）:229-242. (IF5.147)

7. Shanshan Li, Aiqing Xie, Hui Li, Xiang Zou*, Qixiong Zhang*. Aself-assembled, ROS- responsive Janus-prodrug for targeted therapy ofinflammatory bowel disease. Journal of Controlled Release, 2019, 316:66-78. (IF 7.902)

6. Lei Shu, Mingjin Yang,Hang Zhao, Tianfu Li, Ling Yang, Xiang Zou*, Yunwu Li*. Process optimization ina stirred tank bioreactor based on CFD-Taguchi method: A case study. Journal of Cleaner Production, 2019,230: 1074-1084. (IF 6.395)

5. Xiang Zou*, Chi Cheng,Jun Feng, Xiaodan Song, Meng Lin, Shang-Tian Yang*. Biosynthesis of polymalicacid in fermentation: Advances and prospects for industrial application. Critical Review in Biotechnology, 2019,39(3): 408-421.(IF 7.054)

4.Jun Feng,Tianfu Li, Xiao Zhang, Jie Chen, Tiantao Zhao, Xiang Zou*. Efficient production of polymalic acid from xylose mother liquor, anenvironmental waste from the xylitol industry, by aT-DNA-based mutant of Aureobasidiumpullulans. Applied MicrobiologyBiotechnology, 2019, 103（16）：6519-6527.(IF 3.67)

3. Jun Feng,Jing Yang, Wenwen Yang, Jie Chen, Min Jiang, Xiang Zou^*. Metabolome-and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acidproduction from sugarcane molasses. Biotechnologyfor Biofuels, 2018,11: 94. (IF 5.452)

2.Yongkang Wang, Xiaodan Song, Yongjun Zhang, Bochu Wang, XiangZou*. Physiological response ofnitrogen availability on the polymalic acid biosynthesis in Aureobasidium pullulans. Microbial Cell Factories, 2016, 15: 146. (IF 4.402)

1. Xiang Zou, Yipin Zhou,Shang-tian Yang*. Production of polymalic acid and malic acid by Aureobasidium pullulans fermentation andacid hydrolysis. Biotechnology andBioengineering, 2013,110(8):2105-2113. (IF 4.26)

荣誉与奖励

1. 多糖及含羧基类活性成分代谢调控机制及制备技术研究，2020年浙江省自然科学三等奖，2/5

2. 2018年重庆市**学者特聘教授（制药工程设岗学科）

3. 苹果酸及系列衍生物绿色生产关键技术，2017年重庆市技术发明二等奖，1/6

4.药用微生物活性成分代谢调控关键技术及产业化应用，2017年温州市科技进步一等奖，3/5

5．先进技术集成的红霉素生产新工艺，2008年上海市科技进步一等奖，9/15