主要从事干细胞与表观遗传方面研究

论文与著作

1.     GaoR#, Zeng S#, Yang D#, Li X#, Liu W, Gao Y, Bai D, Zhang L, Chen C, Kang Y, WangB, Hong W, Wang M, Yin J, Wang H, Deng Q, Gao S*, Zhang Y*, Chen J*. Resettinghistone modifications during human prenatal germline development. CellDiscovery. 2023 Feb 3;9(1):14. doi: 10.1038/s41421-023-00519-1.

2.     WangM#, Zhao K#, Liu M#, Wang M, Qiao Z, Yi S, Jiang Y, Kou X, Zhao Y, Yin J, Li T,Wang H, Jiang C*, Gao S*, Chen J*.BMP4 preserves the developmental potential of mESCs through Ube2s- andChmp4b-mediated chromosomal stability safeguarding. Protein Cell. 2022Aug;13(8):580-601. doi: 10.1007/s13238-021-00896-x.

3.     Zhao K#,Wang M#, Gao S*, Chen J*. Chromatinarchitecture reorganization during somatic cell reprogramming. CurrentOpinion in Genetics & Development. 2021 Oct 70:104-113.https://doi.org/10.1016/j.gde.2021.07.006

4.     YangG#, Zhang L#, Liu W#, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, LiuM, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X,Zhao Y, Wang H, Wang Y, Gao S*, Chen J*, Jiang C*. Dux-mediated correctionsof aberrant H3K9ac during 2-cell genome activation optimized efficiency ofsomatic cell nuclear transfer. Cell Stem Cell. 2020 Oct5:S1934-5909(20)30452-5. doi: 10.1016/j.stem.2020.09.006.

5.     Li Y#,Zhang Z#, Chen J#, Liu W, Lai W, LiuB, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G,Wong J, Xu G, Wang Z, Wang H, Gao S, Zhu B*. Stella safeguards the oocytemethylome by preventing de novo methylation mediated by DNMT1. Nature.2018 Dec;564(7734):136-140. doi: 10.1038/s41586-018-0751-5.

6.     Li J#,Shen S#, Chen J#, Liu W, Li X, ZhuQ, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C*, Gao S*.Accurate annotation of accessible chromatin in mouse and human primordial germcells. Cell Research. 2018 Nov;28(11):1077-1089. doi:10.1038/s41422-018-0096-5.

7.     He W#,Zhang X#, Zhang Y, Zheng W, Xiong Z, Hu X, Wang M, Zhang L, Zhao K, Qiao Z, LaiW, Lv C, Kou X, Zhao Y, Yin J, Liu W, Jiang Y, Chen M, Xu R, Le R, Li C, WangH, Wan X, Wang H, Han Z, Jiang C*, Gao S*, ChenJ*. ReducedSelf-Diploidization and Improved Survival of Semi-cloned Mice Produced fromAndrogenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b.Stem Cell Reports. 2018 Feb13;10(2):477-493. doi: 10.1016/j.stemcr.2017.12.024.

8.     GaoY#, Chen J#, Li K, Wu T, Huang B,Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, ChenJ, Wang H, Cai T and Gao S. Replacement of Oct4 by Tet1 during iPSC inductionreveals an important role of DNA methylation and hydroxymethylation inreprogramming. Cell Stem Cell, 2013 Apr 4;12(4):453-69. doi:10.1016/j.stem.2013.02.005.

国家自然科学奖二等奖（2020年）

教育部自然科学奖一等奖（2019年）