研究领域

2012年博士毕业于中国药科大学生药学专业；美国耶鲁大学医学院访问学者。

研究方向：中药药效及作用机制研究

具体研究领域：血管内皮功能的调节机制；基于内皮功能紊乱探讨中药的药效及作用机制；中药有效成分的作用靶点发现和相关信号通路研究。

论文与著作

1.            Fan RP^#, Han YW^#(共同第一作者）, Han H, Chen ZD, Yu BY, Kou JP^*, ZhangYY^*(共同通讯作者). DT-13 amelioratesTNF-a-inducednitric oxide production in the endothelium in vivo and in vitro.Biochemical andBiophysical Research Communications, 2018,459:1175-1181IF=2.559

2.           Zhang YY, Li L, Zhao YZ, Han H, HuY, Liang D, Yu BY,Kou JP^*. The Myosin II Inhibitor, Blebbistatin,Ameliorates FeCl₃-inducedArterial Thrombosis via the GSK3β-NF-κBPathway. International Journal ofBiological Sciences, 2017,13(5): 630-639.IF=4.057

3.           Zhang YY, Han YW, Zhao YZ, Lv YN, HuY, Tan YS, Bi XY,Yu BY^*, Kou JP^*. DT-13 amelioratesTNF-α-induced vascularendothelial hyperpermeability via non-Muscle Myosin IIAand the Src/PI3K/Aktsignaling Pathway. Frontiers in Immunology, 2017,8:925IF=5.511

4.           ZhangYY^#, Sun MH^#(共同第一作者),Han YW, Zhai KF, Tang YM, Qin XY, Cao ZY, Yu BY*, KouJP*. The saponin DT-13attenuates tumor necrosis factor-α-induced vascularinflammation associatedwith Src/NF-кB/MAPK pathway modulation.InternationalJournal of Biological Sciences, 2015; 11(8): 970-981 IF=3.982