研究领域

研究方向一：中药的药效物质基础研究

研究方向二：天然药物活性先导化合物的发现结构优化

论文与著作

1.  LI Shengge, ZHANG Qin, WANG Yuetong, LIN Bin, LI Dahong, HUA Huiming, HU Xu^*. β-Carboline alkaloids from the roots of Peganum harmala. Chinese Journal of Natural Medicines, 2024, 22, 171−177.

2. XuHu, Yan Xiao, Jianan Sun, Bao Ji, Shanshan Luo, Bo Wu, Chao Zheng, Peng Wang, Fanxing Xu^*, KeguangCheng Huiming Hua^*, Dahong Li^*. New possible silverlining for pancreatic cancer therapy: hydrogen sulfide and its donors. Acta Pharmaceutica Sinica B, 2021, 11, 1148−1157 .

3. Xu Hu, XiangGao, Gang Gao, Yanbing Wang, Hao Cao, Dahong Li^*, Huiming Hua^*. Discovery of β-carboline-(phenylsulfonyl)furoxanhybrids as potential antibreast cancer agents. Bioorganic & Medicinal Chemistry Letters, 2021, 40:127952. 

4. XuHu, Ziyi Bai, Jian Qiao, Haonan Li, Shengtao Xu, Xianhua Wang, YongnanXu, Jinyi Xu, Huiming Hua^*, Dahong Li^*.Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation. European Journal ofMedicinal Chemistry, 2019,171: 169−179. 

5. XuHu, Runwei Jiao, Haonan Li, Xianhua Wang, Haoda Lyu, Xiang Gao, Fanxing Xu, Zhanlin Li, Huiming Hua, Dahong Li^*. Antiproliferative hydrogen sulfide releasing evodiamine derivatives and their apoptosis inducing properties. European Journal of MedicinalChemistry, 2018, 151:376−388. 

6. XuHu, Dahong Li, Chun Chu, Xu Li, Xianhua Wang, Ying Jia, HuimingHua, Fanxing Xu^*. Antiproliferative effects of alkaloid evodiamine and its derivatives. International Journal of Molecular Sciences, 2018,19: 3403.

7. XuHu, Yan Wang, Xiang Gao, Shengtao Xu, Linghe Zang, Yan Xiao,Zhanlin Li, Huiming Hua^*, Jinyi Xu, Dahong Li^*. Recent progress of oridonin and its derivatives for the treatment of acute myelogenous leukemia. Mini-Reviews in Medicinal Chemistry, 2020, 20: 483−497. 

8. Xu Hu, Ningbo Qin, Jingjing Xue, Siqi Li, Xiaofang Huang, Jianan Sun, Fanxing Xu^*, Zhanlin Li, Dahong Li^*, Huiming Hua^*. Dehydrodiconiferyl alcohol from Silybum marianum(L.) Gaertn accelerates wound healing via inactivating NF-kB pathways in macrophages. Journal of Pharmacy and Pharmacology, 2020, 72: 305−317.

9. Xu Hu, Yan Wang, Jingjing Xue, Tong Han, Runwei Jiao,Zhanlin Li, Weiwei Liu, Fanxing Xu, Huiming Hua^*, Dahong Li^*. Design and synthesis of novel nitrogenmustard-evodiamine hybrids with selective antiproliferative activity. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 4989−4993.

荣誉与奖励

1. 荣获“2021年辽宁省优秀毕业生”称号

2. 荣获2023年辽宁省优秀博士论文

3. 在“开展教学反思，追求教学卓越-对分课堂教学应用”征文比赛活动中荣获校级二等奖