- 单位：中山大学 中山医学院
- 职称：教授
- 职位：
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研究领域
2017年5月获聘中山大学中山医学院教授、博士/硕士研究生导师，国家高层次引进人才青年项目入选者，中山大学“百人计划”引进人才。曾获得国家优秀自费留学生奖学金（2014）和German Stem CellNetwork “Publication of The Year”奖（2015）。 王继厂教授课题组在国家重点研发计划、自然科学基金、广东省“珠江人才计划”等项目支持下，利用单细胞组学、化学生物学和基因组编辑等研究手段，以内源性逆转录病毒等反转录转座子为切入点，进行灵长类早期胚胎发育调控机制和异种嵌合体方向的研究，相关研究成果发表于Nature，Nucleic AcidsResearch, Nature Protocols等学术期刊。
论文与著作
15. Xiao-Yan Ma#, Hong Zhang#, Jian-Xiong Feng, Jia-Li Hu, Bing Yu, Li Luo, Yu-Lu Cao, Shuang Liao, Jichang Wang, Song Gao*. Structures of mammalian GLD-2 proteins reveal molecular basis of their functional diversity in mRNA and microRNA processing. Nucleic Acids Res. 2020; doi: 10.1093/nar/gkaa578.
14. Junjun Xu, Zheng Zheng, Xuguang Du, Bingbo Shi, Jichang Wang, Dengfeng Gao, Qianqian Zhu, Xinze Chen & Jianyong Han. A cytokine screen using CRISPR-Cas9 knock-in reporter pig iPS cells reveals that Activin A regulates NANOG. Stem Cell Research & Therapy. 2020, 11
13. Jia-Li Hu#, He Liang#, Hong Zhang#, Ming-Zhu Yang#, Wei Sun, Peng Zhang, Li Luo, Jian-Xiong Feng, Huajun Bai, Fang Liu, Tianpeng Zhang, Jin-Yu Yang, Qingsong Gao, Yongkang Long, Xiao-Yan Ma, Yang Chen, Qian Zhong, Bing Yu, Shuang Liao, Yongbo Wang, Yong Zhao, Mu-Sheng Zeng, Nan Cao, Jichang Wang, Wei Chen*, Huang-Tian Yang*, Song Gao*. FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Res. 2020, 48(5):2733-2748.
12. Yasamin Dabiri, Rodrigo A Gama-Brambila, Katerina Taškova, Kristina Herold, Stefanie Reuter, James Adjaye, Jochen Utikal, Ralf Mrowka, Jichang Wang, Miguel A Andrade-Navarro, Xinlai Cheng. Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs. iScience. 2019, 12: 168-181.
11. Yongming Wang#, Diana Pryputniewicz-Dobrinska#, Enikö Nagy#, Christopher Kaufman, Manvendra Singh, Stephen Yant, Jichang Wang, Anna dalda, M Kay, Zoltán Ivics*, Zsuzsanna Izsvák*. Regulated Complex Assembly Safeguards the Fidelity of Sleeping Beauty Transposition. Nucleic Acids Res. 2017. 45(1): 311-326. doi: 10.1093/nar/gkw1164
10. Liang Hu#, Jichang Wang#, Hongyi Zhu, Xiaowei Wu, Lu Zhou, Yichen Song, Suhua Zhu, Maojuan Hao, Chao Liu, Yue Fan, Yu Wang, Qingping Li. Ischemic postconditioning protects the heart against ischemia-reperfusion injury via neuronal nitric oxide synthase in the sarcoplasmic reticulum and mitochondria. Cell Death Dis. 2016; 7: e2222. Doi: 10.1038/cddis.2016.108.
9. Jichang Wang, Manvendra Singh, Chuanbo Sun, Daniel Besser, Alessandro Prigione, Zoltán Ivics, Laurence D. Hurst*, Zsuzsanna Izsvák*. Isolation and Cultivation of Naïve-like Human Pluripotent Stem Cells based on HERVH Expression. Nat protoc. 2016; 11(2): 327-346. doi: 10.1038/nprot.2016.016. (Featured in Nature Protocols; Cover article)
8. Sabine Klawitter#, Nina V. Fuchs#, Kyle R. Upton#, Martin Muñoz-Lopez#, Ruchi Shukla, Jichang Wang, Marta Garcia-Canadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez*, Geoffrey J. Faulkner*, Gerald G. Schumann*. Reprogramming triggers endogenous L1, Alu and SVA retrotransposition in human induced pluripotent stem cells. Nat Commun. 2016; 7: 10286. doi: 10.1038/ncomms10286.
7. Zsuzsanna Izsvák*, Jichang Wang, Manvendra Singh, Dixie L. Mager, Laurence D. Hurst. Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity? BioEssays. 2016; 38(1): 109-117. (Invited review)
6. Jichang Wang#, Gangcai Xie#, Manvedra Singh, Avazeh T. Ghanbarian, Tamás Raskó, Attila Szvetnik, Huiqiang Cai, Daniel Besser, Alessandro Prigione, Nina V. Fuchs, Gerald G. Schumann, Wei Chen, Matthew C. Lorincz, Zoltán Ivics, Laurence D. Hurst*, Zsuzsanna Izsvák*. Primate-specific endogenous retrovirus driven transcription defines naïve-like stem cells. Nature. 2014; 516(7531): 405-409. doi: 10.1038/nature13804.
5. Yongming Wang#, Jichang Wang#, Anatharam Devaraj, Manvendra Singh, Ana Jimenez Orgaz, Jia-Xuan Chen, Matthias Selbach, Zoltán Ivics*, Zsuzsanna Izsvák*. Suicidal autointegration of sleeping beauty and piggyback transposons in eukaryotic cells. PLoS Genet. 2014; 10(3): e1004103. doi: 10.1371/journal.pgen.1004103.
4. Wenli Zhang, Manish Solanki, Melanie Ebel, Chistina Rauschhuber, Nadine Müther, Jichang Wang, Chuanbo Sun, Zsuzsanna Izsvák, Anja Ehrhardt. Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells. PLoS ONE. 2013; 8(10): e76771. doi: 10.1371/journal.pone.0076771.
3. Wenli Zhang, Martin Muck-Hausl, Jichang Wang, Chuanbo Sun, Maren Gebbing, Csaba Miskey, Zoltán Ivics, Zsuzsanna Izsvák and Anja Ehrhardt. Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive Sleeping Beauty transposase for somatic integration. PLoS ONE. 2013; 8(10): e75344. doi: 10.1371/journal.pone.0075344.
2. Ivana Grabundzija#, Jichang Wang#, Attila Sebe#, Zsuzsanna Erdei, Robert Kajdi, Anantharam Devaraj, Doris Steinemann, Károly Szuhai, Ulrike Stein, Tobias Cantz, Axel Schambach, Christopher Baum, Zsuzsanna Izsvák*, Balázs Sarkadi*, and Zoltán Ivics*. Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells. Nucleic Acids Res. 2013; 41(3): 1829-1847. doi: 10.1093/nar/gks1305.
1. Ruizhen Shi, Jichang Wang, Songhua Huang, Xiaojun Wang, Qingping Li. Angiotensin II induces vascular endothelial growth factor synthesis in mesenchymal stem cells. Exp Cell Res. 2009; 315(1): 10-15. doi: 10.1016/j.yexcr.2008.09.024.
经费来源及在研项目：
1. 中山大学基本科研业务费青年教师重点培育项目（2019 - 2020，项目负责人）
2. 国家自然科学基金面上项目（2019.1 - 2022.12，项目负责人）
3. 国家重点研发计划——“干细胞及转化研究”专项（2018.7 - 2022.12，课题负责人）
4. 国家重点研发计划——“干细胞及转化研究”专项（2018.7 - 2022.12，学术骨干）
5. 国家高层次引进人才青年项目（2017.1 - 2020.12，项目负责人）
6. 广东省“珠江人才计划”引进创新创业团队（2017，核心骨干）
7. 中山大学“百人计划”引进人才科研启动经费（2017，项目负责人）
8. Helmholtz Postodoc Programme（2015，30万欧元，PI）