丁英
  • 单位：中山大学   中山医学院组胚教研室
  • 职称：教授
  • 职位：教研室主任/党支部书记
  • 出生：1975.12
  • 性别：女
  • 社会职务： 广东省解剖学会理事
  • 微博：

研究领域

丁英，教授，医学博士，博士生导师，现任中山大学中山医学院组织学与胚胎学教研室主任和党支部书记。2002年中山大学中山医学院硕士毕业并留校任教至今；2009年获中山大学人体解剖与组织胚胎学博士学位；2015年-2016年在美国印第安纳大学医学院神经科学研究中心做访问学者。作为主持人已获得国家自然科学基金3项、广东省自然科学基金3项、广东省中医药局科学基金和教育部高校基本科研业务费中山大学青年教师培育计划项目各1项。作为主要合作者参与了国家自然科学基金重点项目，国家科技部重点研发项目，广东省科技计划项目和广州市科技计划项目各一项。发表相关SCI论文42篇(第一作者/通讯作者16篇)。主要研究方向：组织工程干细胞源性神经网络组织移植联合电针/电刺激治疗修复脊髓损伤的机制研究。

主持的科研项目

1.国家自然科学基金-面上项目，82074528，电针调控A2星形胶质细胞促进移植NSC源性神经元与损伤脊髓的神经元形成突触的机制研究。2021-01-01到2024-12-31，55万，在研，主持

2.国家自然科学基金-面上项目，81774397，电针通过NT-3介导炎症调节以促进移植的MSC源性神经网络在损伤脊髓内存活及功能性整合的研究，2018/01-2021/12，60 万元，在研，主持

3.广东省自然科学基金-自由申请项目，2017A030313674，督脉电针联合TrkC-MSCs移植协同抑制炎症反应促进损伤脊髓神经再生的机制研究，2017/10-2020/10，10万，主持

4.国家重点研发计划项目，2017YFA0104702，基于间充质干细胞神经组织模块修复周围神经缺损的基础与临床研究，2017/07-2021/12，689万，在研，参与（分配基金90万）

论文与著作

(#Co-first author; *Corresponding Author)

1.       HaoyuXu*, Yang Yang*, Qing-Wen Deng, Bao-Bao Zhang, Jing-Wen Ruan, Hui Jin, Jun-HuaWang, Jiale Ren, Bin Jiang, Jia-Hui Sun, Yuan-Shan Zeng#, Ying Ding#. Governor Vessel electro-acupuncture promotes the intrinsic growth ability of spinal neurons throughactivating CGRP/αCaMKII/NT-3 pathway after spinal cord injury. Journal ofNeurotrauma,2020

2.       Jin H#, Zhang YT#,Yang Y, Wen LY, Wang JH, Xu HY, Lai BQ, Feng B, Che MT, Qiu XC, Li ZL, Wang LJ,Ruan JW, Jiang B, Zeng X, Deng QW, Li G, DingY*, Zeng YS*. Electroacupuncture Facilitates the Integration of Neural StemCell-Derived Neural Network with Transected Rat Spinal Cord. Stem Cell Reports.2019, 12(2):274-289.

3.       Al-Ali H#, Ding Y#, Slepak T#, Wu W,Sun Y, Martinez Y, Xu XM, Lemmon VP, Bixby JL. The mTOR substrate S6 Kinase 1(S6K1) is a negative regulator of axon regeneration and a potential drug targetfor Central Nervous System injury. J Neurosci. 2017, 37(30):7079-7095. 

4.       Zhang YT, Jin H, Wang JH, Wen LY, Yang Y, Ruan JW, Zhang SX, Ling EA, Ding Y*, Zeng YS*. Tail NerveElectrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neuronsand Alleviate Muscle Atrophy after Spinal Cord Transection in Rats. NeuralPlast. 2017;2017:7351238.

5.       Yang XH#, Ding Y#,Li W, Zhang RY, Wu JL, Ling EA, Wu W*, Zeng YS*, Effects of electroacupunctureand the retinoid X receptor (RXR) signalling pathway on oligodendrocytedifferentiation in the demyelinated spinal cord of rats, Acupunct Med, 2017, 35(2):122-132.

6.       Ding Y, Zhang RY, He B, Liu Z, Zhang K, Ruan JW, LingEA, Wu JL, Zeng YS. Combination of electroacupuncture and graftedmesenchymal stem cells overexpressing TrkC improves remyelination and function in demyelinated spinal cord of rats.  Sci Rep. 2015 Mar 16;5:9133. doi:10.1038/srep09133.

7.       Ding Y, Yan Q, Ruan JW, Zhang YQ, Li WJ, Zeng X, HuangSF, Zhang YJ, WuJL, Fisher D, Dong H, Zeng YS. Electroacupuncture promotes the differentiation oftransplanted bone marrow mesenchymal stem cells over expressing TrkC intoneuron-like cells in transected spinal cord of rats. Cell Transplant, 2013, 22(1):65-86.

8.       Ding Y, Yan Q, Ruan JW, Zhang YQ, Li WJ,Zeng X, Huang SF, Zhang YJ, Wang S, Dong H, Zeng YS. Bone marrow mesenchymalstem cells and electro-acupuncture downregulate the inhibitor molecules andpromote the axonal regeneration in the transected spinal cord of rats. Cell Transplant, 2011, 20(4):475-491.

9.       HuangSF, Ding Y(co-firstauthor), Ruan JW, Zhang W, WuJL, He B, Zhang YJ, Li Y, Zeng YS. An experimentalelectro-acupuncture study in treatment of the rat demyelinated spinal cordinjury induced by ethidium bromide. Neurosci Res, 2011, 70(3): 294-304.

10.    Ding Y, Yan Q, Ruan JW, Zhang YQ, Li WJ, Zhang YJ, Li Y, Dong H, Zeng YS. Electro-acupuncture promotes survival,differentiation of the bone marrow mesenchymal stem cells as well as functionalrecovery in the spinal cord-transected rats. BMC neurosci, 2009, 10(1):35-47.

11.    Liu Z, Ding Y, Zeng YS. Anew combined therapeutic strategy of governor vessel electro-acupuncture andadult stem cell transplantation promotes the recovery of injured spinal cord.Current Medicinal Chemistry, 2011,18(33):5165-71.

12.   Zeng YS, Ding Y, Wu LZ, Guo JS, Li HB, Wong WM,Wu WT. Co-transplantation of schwann cells promotes thesurvival and differentiation of neural stem cells transplanted into the injuredspinal cord. Dev Neurobiol, 2005,27(1)20-26.

13.    Huang LJ, Li G, Ding Y, SunJH, Wu TT, Zhao W, Zeng YS. LINGO-1 deficiency promotes nerve regenerationthrough reduction of cell apoptosis, inflammation, and glial scar after spinalcord injury in mice. Exp Neurol. 2019 320:112965.

14.    Lai BQ, Che MT, Feng B, Bai YR, Li G, Ma YH, Wang LJ, Huang MY, Wang YQ,Jiang B, Ding Y, ZengX, Zeng YS. Tissue-Engineered Neural Network Graft Relays ExcitatorySignal in the Completely Transected Canine Spinal Cord. Adv Sci (Weinh). 2019, 6(22):1901240. 

15.    Ma YH, Zeng X, Qiu XC, Wei QS, CheMT,Ding Y, Liu Z, Wu GH, Sun JH, Pang M, Rong LM, LiuB, Aljuboori Z, Han I, Ling EA,Zeng YS. Perineurium-like sheath derived fromlong-term surviving mesenchymal stem cells confers nerve protection to theinjured spinal cord.Biomaterials. 2018 ,160:37-55.

16.    Qiu XC, Jin H, Zhang RY, Ding Y, Zeng X, Lai BQ, Ling EA, WuJL, Zeng YS. Donor mesenchymal stem cell-derived neural-like cellstransdifferentiate into myelin-forming cells and promote axon regeneration inrat spinal cord transection. Stem Cell Res Ther. 2015, 6:105. 

17.    Li G, Che MT, Zhang K, Qin LN,Zhang YT, Chen RQ, Rong LM, Liu S, DingY, Shen HY, Long SM, Wu JL, Ling EA, Zeng YS. Graft of the NT-3persistent delivery gelatin sponge scaffold promotes axon regeneration,attenuates inflammation, and induces cell migration in rat and canine withspinal cord injury. Biomaterials. 2016, 83:233-48.

18.   Li WJ, Li SM, Ding Y, He B, Keegan J, Dong H, RuanJW, Zeng YS Electro-acupuncture upregulates CGRP expression after rat spinalcord transection. Neurochem Int, 2012, 61(8):1397-1403

19.    Yan Q, Ruan JW, Ding Y, Li WJ, Li Y, Zeng YS.Electro-acupuncture promotes differentiation of mesenchymalstem cells, regeneration of nerve fibers and partial functional recovery afterspinal cord injury. Exp ToxicolPathol, 2011, 63(1-2):151-156. 

20.   Zhang YJ, Zhang W, Lin CG, Ding Y, Huang SF, Wu JL, Li Y, Dong H,Zeng YS. Neurotrophin-3gene modified mesenchymal stem cells promoteremyelination and functional recovery in the demyelinated spinal cord of rats.J Neurol Sci, 2012, 313(1-2):64-74.

21.    Zhang W, Zeng YS, Wang JM, Ding Y, Li Y, Wu W. Neurotrophin-3 improves retinoic acid-inducedneural differentiation of skin-derived precursors through a p75NTR-dependentsignaling pathway. Neurosci Res, 2009, 64(2): 170-176. 

22.    Zhang YQ, Zeng X, He LM, Ding Y, Li Yan, Zeng YS. NT-3 gene modified Schwann cells promoteTrkC gene modified mesenchymal stem cells to differentiate into neuron-likecells in vitro. Anat Scie Inter, 2010, 85(2):61-67.

23.    He GH, Ruan JW, Zeng YS, Zhou X, DingY, Zhou GH. Improvement in acupoint selection for acupuncture of nervessurrounding the injury site: electro-acupuncture with Governor vessel withlocal meridian acupoints. Neural Regen Res.2015, 10(1):128-35. 

24.   Liu Z, He B, Zhang RY, Zhang K, DingY, Ruan JW, Ling EA, Wu JL, Zeng YS. Electroacupuncture Promotes theDifferentiation of Transplanted Bone Marrow Mesenchymal Stem Cells Pre-Inducedwith Neurotrophin-3 and Retinoic Acid into Oligodendrocyte-Like Cells inDemyelinated Spinal Cord of Rats. Cell Transplant. 2014 May 22. [Epub ahead ofprint]

25.    Zhang K, Liu Z, Li G, Lai BQ,Qin LN, Ding Y, Ruan JW, ZhangSX, Zeng YS. Electro-acupuncture promotes the survival and differentiationof transplanted bone marrow mesenchymal stem cells pre-induced withneurotrophin-3 and retinoic Acid in gelatin sponge scaffold after rat spinalcord transection. Stem Cell Rev. 2014, 10(4):612-25.

26.    Li WJ, Pan SQ, Zeng YS, Su BG, Li SM, Ding Y, Li Y, Ruan JW. Identification of acupuncture-specific proteins in the process ofelectro-acupuncture after spinal cord injury. Neurosci Res, 2010, 67(4):307-316. 

27.    Feng Y, Huang J, Ding Y,Xie F, Shen X. Tamoxifen-induced apoptosis of rat C6 glioma cells via PI3K/Akt,JNK and ERK activation. Oncol Rep, 2010, 24(6):1561-1567.

28.    Guo JS, Zeng YS, Li HB, Huang WL, Liu RY, Ding Y, Wu LZ, Cai DZ. Cotransplant of neural stem cells and NT-3 gene modified Schwanncells promote the recovery of transected spinal cord injury. Spinal Cord, 2007,45:15-24.

参编教材：

1．2018年作为编委参编《组织学与胚胎学实验指导》国家卫生健康委员会“十三五”规划教材配套教材，李继承主编；人民卫生出版社，2018年10月第1版，184千字。

2. 2018年作为副主编参编《组织学与胚胎学-同步精讲精练》，主编：郭家松；世界图书出版公司，2018年11月第1版，369千字。

3. 2014年作为编委参编《组织学与胚胎学实验指导》，主编：曾园山 李朝红；人民卫生出版社，2014年5月，146千字。

4. 2012年作为编委参编《A LaboratoryManual of Histology and Embryology 组织学与胚胎学实验指导（英文版）》，主编：曾园山 常青 杨雪松；人民卫生出版社，2012年7月，194千字。

5. 2012年作为编委参编《组织学与胚胎学实验技术》，主编：李继承，人民卫生出版社，2010年5月，885千字。

6. 2010年作为编委参编《实用细胞培养技术》，主编：谭玉珍 主审：章静波；高等教育出版社，2010年11月，520千字。


荣誉与奖励

1.2018年2月，“督脉经穴电针通过NT-3介导移植的成体干细胞修复脊髓损伤的研究”获广东省自然科学奖二等奖，排名第2；

2.“基于转化医学思想的心血管系统学科整合教学模式探索”获中山大学第八届教学成果家二等奖，排名第4；

3.“以教材创新建设为契机提升组织学与胚胎学课程教学水平的探索与实践”获中山大学第八届教学成果家二等奖，排名第6。

4.“推进组织学与胚胎学双语教学培养高素质医学人才”荣获2008年中山大学第八届教学成果家一等奖，排名第4。

5.《消化腺》荣获“中山大学2006年教学电子演示文稿（PPT）大赛”二等奖