研究领域

现任中山大学中山医学院教授、博士生导师，广东省青年珠江学者、中山大学“百人计划”二期引进人才。张宏波教授相关成果发表于Science、ScienceTranslational Medicine、Nature Reviews Endocrinology、Kidney International 等期刊，并获第一发明人国际专利2项。实验室综合运用生物信息学、生化与分子生物学、细胞生物学等手段研究能量代谢，尤其是线粒体功能对骨骼肌干细胞等成体干细胞功能维持和衰老的调节。现阶段主要研究方向如下：1. 成体干细胞衰老机制研究；2. 能量代谢和线粒体对成体干细胞功能和命运决定的影响；3. 骨骼肌稳态对系统能量代谢的调节。作为课题负责人承担重点研发计划重点专项1项、国家自然科学基金面上项目1项、广东省自然科学基金项目1项和广州市基础与应用基础研究项目1项。

承担课题

科技部，重点研发计划重点专项，2019YFA0801703, 内共生代谢物与命运决定因子互作调控组织发育与发病过程的分子机理，2019-12至2024-11，779万元，在研，主持

国家自然科学基金委员会，面上项目，31871370，乙酰化转移酶KAT2A对骨骼肌干细胞分化的调节作用及机理研究，2019-01至2022-12，60万元，在研，主持

中山大学，青年教师重点培育项目，19kyzd37，人肢体发育过长中细胞分化关键调控机制及临床前应用研究，2019-01至2020-12，30万元，在研，主持

广东省科技厅，广东省自然科学基金-自由申请，2018A030313655，DMD疾病骨骼肌干细胞线粒体功能研究，2018-05至2021-04，10万元，在研，主持

广州市科委，广州市基础与应用基础研究项目，乙酰化转移酶KAT2A对骨骼肌损伤修复与再生的调控作用及机理研究，2020-04至2022-03，20万元，在研，主持

中山大学， “百人计划”引进急需青年杰出人才，2017-08至2022-8，300万元，在研，主持

瑞士Carigest基金会，干细胞研究奖励基金，Controls of muscle stem cells function byacetyltranferase KAT2A, 2015-01至2016-12，13.5万瑞士法郎（约合人民币90万元），结题，主持

论文与著作

1            Wang, S., Zhang, B., Addicks, G.C., Zhang, H., Keir, J. M.*, & Zhang, H.*. Muscle Stem CellImmunostaining. Current Protocols in Mouse Biology, 8(3), e47.(2018) (*, correspondingauthors)

 2            Zhang, H., Menzies,K. J., & Auwerx, J. The role of mitochondria in stem cell fate and aging. Development,145(8). (2018)

 3            Addicks, G. C., Marshall, P., Jasmin, B. J.,Renaud, J. M., Zhang, H. *, & Menzies, K. J. * CriticalAssessment of the mdx Mouse with Ex Vivo Eccentric Contraction of the DiaphragmMuscle. Current Protocols in Mouse Biology, 8(3), e49. (2018) (*, corresponding authors)

 4        Zhang, H., Ryu, D., Wu, Y., Gariani, K.,Wang, X., Luan, P., D'Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R.,Schoonjans, K., Menzies, K. J. & Auwerx, J. NAD+ repletion improvesmitochondrial and stem cell function and enhances life span in mice. Science,352, 1436-1443, (2016).

 5        Ryu, D.#, Zhang,H.#, Ropelle, E. R.#, Mazala, D. G., Mouchiroud, L., Sorrentino,V., Campbell, M. D., Ali, A. S., Bellemin, S., Lyer, S., Gariani, K., Sauve, A.A., Canto, C., Conley, K. E., Walter, L., Lovering, R. M., Chin, E. R.,Marcinek, D. J. Menzies, K. J., & Auwerx, J. NAD+ repletion improvesmuscular dystrophy by countering increased levels of PARylation. ScienceTranslational Medicine, 361, 361ra139 (2016). (#, equal contribution).

 6     Menzies, K. J.#, Zhang,H.#, Katsyuba, E.# & Auwerx, J. Protein acetylation inmetabolism - metabolites and cofactors. Nature Reviews Endocrinology,12, 43-60, (2016). (#, equal contribution)

 7        Spichtig, D.#, Zhang,H.#, Mohebbi, N., Pavik, I., Petzold, K., Stange, G., Saleh, L.,Edenhofer, I., Segerer, S., Biber, J., Jaeger, P., Serra, A. L. & Wagner,C. A. Renal expression of FGF23 and peripheral resistance to elevated FGF23 inrodent models of polycystic kidney disease. Kidney International,85, 1340-1350, (2014). (#, equal contribution).

 （其他论文）

1        Zhu, X., Shen, W., Yao, K., Wang, H.,Liu, B., Li, T., Song, L., Diao, D., Mao, G., Huang, P., Li, C., Zhang,H., Zou, Y., Qiu, Y., Zhao, Y., Wang, W., Yang, Y., Hu, Z., Auwerx, J.,Loscalzo, J., Zhou, Y., & Ju, Z. Fine-Tuning of PGC1alpha ExpressionRegulates Cardiac Function and Longevity. Circulation Research,125, 707-719 (2019).

 2        Lahiri, S., Kim, H., Garcia-Perez, I.,Reza, M. M., Martin, K. A., Kundu, P., Cox, L. M., Selkrig, J., Posma, J. M., Zhang,H., Padmanabhan, P., Moret, C., Gulyas, B., Blaser, M. J., Auwerx, J.,Holmes, E., Nicholson, J., Wahli, W., & Pettersson, S. The gut microbiotainfluences skeletal muscle mass and function in mice. Science Translational Medicine, 11,  (2019).

 3         Li, H., Wang, X., Rukina, D., Huang,Q., Lin, T., Sorrentino, V., Zhang, H., Bou Sleiman, M., Arends,D., McDaid, A., Luan, P., Ziari, N., Velazquez-Villegas, L. A., Gariani, K.,Kutalik, Z., Schoonjans, K., Radcliffe, R. A., Prins, P., Morgenthaler, S.,Williams, R. W., & Auwerx, J. An Integrated Systems Genetics and OmicsToolkit to Probe Gene Function. Cell Systems, 6(1), 90-102 e104(2018).

 4         Sorrentino, V., Romani, M.,Mouchiroud, L., Beck, J. S., Zhang, H., D'Amico, D.,Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., Counts, S. E., &Auwerx, J. Enhancing mitochondrial proteostasis reduces amyloid-betaproteotoxicity. Nature, 552(7684), 187-193. (2017)

 5        Gariani, K.,Ryu, D., Menzies, K. J., Yi, H. S., Stein, S., Zhang, H., Perino,A., Lemos, V., Katsyuba, E., Jha, P., Vijgen, S., Rubbia-Brandt, L., Kim, Y.K., Kim, J. T., Kim, K. S., Shong, M., Schoonjans, K., Auwerx, J. Inhibitingpoly ADP-ribosylation increases fatty acid oxidation and protects against fattyliver disease. Journal of Hepatology, 66, 131-142, (2017).

 6        Rabhi, N., Denechaud, P. D., Gromada, X.,Hannou, S. A., Zhang, H., Rashid, T., Salas, E., Durand, E.,Sand, O., Bonnefond, A., Yengo, L., Chavey, C., Bonner, C., Kerr-Conte, J.,Abderrahmani, A., Auwerx, J., Fajas, L., Froguel, P. & Annicotte, J. S.KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress byControlling the Unfolded Protein Response. Cell Reports, 165,1051-1061, (2016).

7       Gariani,K., Menzies, K. J., Ryu, D., Wegner, C. J., Wang, X., Ropelle, E. R., Moullan,N., Zhang, H., Perino, A., Lemos, V., Kim, B., Park, Y. K.,Piersigilli, A., Pham, T. X., Yang, Y., Siah Ku, C., Koo, S. I., Fomitchova,A., Canto, C., Schoonjans, K., Sauve, A. A., Lee, J. Y. & Auwerx, J.Eliciting the mitochondrial unfolded protein response via NAD repletionreverses fatty liver disease. Hepatology, 63, 1190-1204, (2015).

8        Ryu, D., Jo, Y. S., Lo Sasso, G., Stein,S., Zhang, H., Perino, A., Lee, J. U., Zeviani, M., Romand, R.,Hottiger, M. O., Schoonjans, K. & Auwerx, J. A SIRT7-dependent acetylationswitch of GABPbeta1 controls mitochondrial function. Cell Metabolism,20, 856-869, (2014).

 9        Pirinen, E.,Canto, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K.J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., Li, W., Timmers,S., Imhof, R., Verbeek, J., Pujol, A., van Loon, B., Viscomi, C., Zeviani, M.,Schrauwen, P., Sauve, A. A., Schoonjans, K. & Auwerx, J. PharmacologicalInhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and MitochondrialFunction in Skeletal Muscle. Cell Metabolism, 19, 1034-1041,(2014).

 10       Wang, Q., Zhang, H., Zhao, B. & Fei,H. IL-1β caused pancreatic beta-cells apoptosis is mediated in part byendoplasmic reticulum stress via the induction of endoplasmic reticulum Ca²⁺release through the c-Jun N-terminal kinase pathway. Molecular andCellular Biochemistry, 324, 183-190, (2009).

荣誉与奖励

广东省青年珠江学者

瑞士生理学学会青年科学家奖