个人信息

姓名，张春翌; 学历，博士; 职称,讲师

电子邮件：cyzhang@fudan.edu.cn

通信地址： 徐汇区东安路130号西7号楼302

工作经历 

2011.12-2012.12 美国克利夫兰医学研究中心（cleveland clinic）,访问学者

2004/1-至今，  复旦大学基础医学院，生物化学与分子生物学系，讲师

2002.8-2003.12复旦张江生物医药股份有限公司,研发工程师 

研究方向

II型跨膜丝氨酸蛋白酶的结构和功能研究

主要教学课程 

正常人体形态与功能学概论IA

正常人体形态与功能学概论IB

五年制生物化学

研究生高级生化试验

本科生生物化学实验课

科研项目

1．CDK11p58在细胞周期中的翻译调控机制研究(批准号:31100977)，国家自然科学基金青年项目，2012/01-2014/12，主持。

2．Hepsin的脱落、激活机制研究及功能性底物的寻找（批准号：81772948）,国家自然科学基金面上项目， 2018/01-2021/12,主持。

期刊论文：（包括教学与科研）

1. Qianqian Cai,Yiwei Dong, Rong Wang, Bing Qi, Junxia Guo, Jing pan,Yuanyuan Liu, Chunyi Zhang*(共同通讯作者), XingzhongWu*, MiR-124 inhibits the migration and invasion of human hepatocellularcarcinoma cells by suppressing integrin αV expression, Sci Rep. 2017 Jan 17;7:40733.

1. 2.       Mingming Zhang, Junjie Zhao,Wenyi Tang, Yanru Wang, Peike Peng, Lili Li, Shushu Song, Hao Wu, Can Li,Caiting Yang, Xuefei Wang*, ChunyiZhang*(共同通讯作者), Jianxin Gu. High Hepsinexpression predicts poor prognosis in Gastric Cancer, Sci Rep. 2016 Nov 14;6:36902.

2. 3.       Mingming Zhang, Jianxin Gu, Chunyi Zhang*, Hepatitis B virus X proteinbinding to hepsin promotes C3 production by inducing IL-6 secretion fromhepatocytes, Oncotarget. 2016 Feb 16; 7(7):7780-800.

3. 4.       ChunyiZhang, Mingming Zhang, Qingyu Wu, Jianhao Peng, YuanyuanRuan, Jianxin Gu, Hepsin inhibits CDK11p58 IRES activity by suppressing unrexpression and eIF-2α phosphorylation in prostate cancer, cellular signaling,2015 Apr; 27(4):789-97.

4. 5.       Yayun Chi1, Chunyi Zhang1 (共同第一作者), HongliangZong, Yi Hong, Xiangfei Kong, Haiou Liu, Weiying Zou, Yanlin Wang, XiaojingYun, Jianxin Gu, Thr-370 is responsible for CDK11(p58) autophosphorylation, dimerization,and kinase activity. J Biol Chem, 2011,286(3):1748-1757.

5. 6.       ChunyiZhang, Ping Hu, Da Fu, Wei Wu, ChengYou Jia, XuChao Zhu,XingZhong Wu, 3-Sulfo-Lex Is Important for Regulation of Integrin Subunit αV.Biochemistry, 2010，49: 7811–7820.

6. 7.       Shenghan Chen, Pengxiu Cao,Ningzheng Dong, Jianhao Peng, ChunyiZhang, Hao Wang, Tiantian Zhou, Junhua Yang, Yue Zhang,Elizabeth E Martelli, Sathyamangla V Naga Prasad, Rachel E Miller, Anne-MarieMalfait, Yiqing Zhou , Qingyu Wu, PCSK6-mediated corin activation is essentialfor normal blood pressure, Nat Med. 2015, 21(9):1048-53.

7. 8.       Wei Wu, Yi Wei Dong, Peng Cheng Shi, Mei Yu, Da Fu, Chun Yi Zhang, Qian Qian Cai, Qian Lei Zhao,† Ming Peng, Li Hui Wu,† and Xing Zhong Wu, Regulation of integrin αV subunit expression by sulfatide inhepatocellular carcinoma cells. J Lipid Res.2013, 54(4):936-52.

8. 9.       Weibin Wu, Zhichao Sun, Jingwen Wu, Xiaomin Peng, Huacheng Gan, Chunyi Zhang, Lingling Ji, Jianhui Xie, Haiyan Zhu, Shifang Ren, Jianxin Gu and Songwen Zhang, Trihydrophobin 1Phosphorylation by c-Src Regulates MAPK/ERK Signaling and Cell Migration, PlosOne, 2012, 7(1):e29920.

参编教材

1．生物化学（医学研究生入学考试精要丛书），复旦大学出版社，2005年10月第一版。

获奖：（包括教学与科研）

1．2017年生物化学与分子生物学系教学比赛二等奖