曹靖
  • 单位：郑州大学   基础医学院人体解剖学系
  • 职称：教授
  • 职位：系主任，博导
  • 出生：197303
  • 性别：女
  • 社会职务： 河南省解剖学会常务理事
  • 微博：

研究领域

神经病理性疼痛的表观遗传学分子机制

1、国家自然科学基金面上项目， 组蛋白乙酰化失调导致钾离子通道Kv1.2沉默引起神经痛的分子机制及代谢干预策略 在研，主持

2 国家自然科学基金面上项目，  去甲基化酶TET1参与围手术期应激延迟术后切口痛的表观遗传调控机制，在研，主持

3 国家自然科学基金面上项目，“ microRNA30b/96/182 调控电压门控钠离子通道1.7参与神经病理性疼痛的作用机制” ，结项， 参与第二

4 国家自然科学基金青年项目， “SCN9A 在外周神经结扎诱发的镜像痛中的机制及与胶质细胞信号传导的双相作用”， 已结题， 主持


论文与著作

1.      Li L, Shao J, Wang J, Liu Y, Zhang Y, Zhang M, Zhang J, Ren X, Su S, LiY, Cao J, * (共通讯) Zang W. MiR-30b-5p attenuatesoxaliplatin-induced peripheral neuropathic pain through the voltage-gatedsodium channel Nav1.6 in rats. Neuropharmacology（IF=4.367）.2019 May 3;153:111-120.

2.      Li Z , Guo Y , Ren X , Rong L , Huang M , Cao J * (共通讯),Zang W . HDAC2, but not HDAC1, regulates Kv1.2 expression to mediateneuropathic pain in CCI rats.Neuroscience（IF=3.244）.2019 Jun 1;408:339-348.

  1. 3.      Weihua Cai(#), Qingzan Zhao(#), Jinping Shao, Jingjing Zhang, Lei Li,Xiuhua Ren,Songxue         Su, Qian Bai,Ming Li, Xuemei Chen, Jian Wang, Jing Cao* (共通讯)&Weidong Zang*. MicroRNA-182 Alleviates Neuropathic Pain by Regulating Nav1.7 FollowingSpared Nerve Injury in Rats. Scientific Reports (IF= 4.122).13 November, 2018.DOI:10.1038/s41598-018-34755-3.

  2. 4.      Jinping Shao(#), Ruiyan Xu(#) , Ming Li, Qingzan Zhao, Xiuhua Ren, ZhihuaLi, Jing Cao*(共通讯), Weidong Zang*.Glucocorticoidreceptor inhibit the activity of NF-κB through p38 signaling pathway in spinalcord in the spared nerve injury rats. Life Sciences (IF=3.234). 208 (2018)268–275

  3. 5.      Di Wu(#), Lingfeng Chen, Shuangliang Ma, Huiying Luo, Jing Cao*(共通讯),Runfeng Chen* , Zheng Duan*, and Francois Mathey*. Synthesis of1,3-Azaphospholes with Pyrrolo[1,2-a]quinoline Skeleton and Their OpticalApplications. Org. Lett. (IF=6.492). 2018, 20 (13), pp 4103–4106

  4. 6.      Cai W, Wu S, Pan Z, Xiao J, Li F, Cao J, Zang W, Tao YX.Disrupting interaction of PSD-95 with nNOS attenuates hemorrhage-inducedthalamic pain. Neuropharmacology. (IF= 4.249). 2018 Oct; 141:238-248.

  5. 7.      Haiyang Huang, Huiying Luo, Guanyu Tao, Weihua Cai, Jing Cao*(共通讯),Zheng Duan*, and François Mathey*. Selective Synthesis of (Z)‑Diazadiphosphafulvalenefrom 2,2′-bis-Azaphosphindole. Org. Lett (IF=6.492).  2018, 20, 1027−1030

  6. 8.      Zhisong Li* , Yaru Li,* , Jing Cao, Xuemin Han , Weihua Cai,Weidong Zang, Jitian Xu, Wei Zhang Membrane protein Nav1.7 contributes to thepersistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG)of SMIR rats model. BMC Anesthesiology (IF= 1.788) (2017) 17:150

  7. 9.      Bo Xu(#), Jing Cao(#)(共一), Jun Zhang, Shaogen Wu,Shushan Jia, Kai Mo, Guihua Wei, Lingli Liang, Xuerong Miao, Alex BekkerandYuan-Xiang Tao*. Role of microRNA-143 in nerve injury-induced upregulationof Dnmt3a expression in primary sensory neurons, Frontiers in Molecular  Neuroscience.(IF=3.902), 2017.11.9. doi:10.3389/fnmol.2017.00350

  8. 10.   Songxue Su(#), Jinping Shao(#), Qingzan Zhao, Xiuhua Ren, Weihua Cai, LeiLi, Qian Bai, Xuemei Chen, Bo Xu, Jian Wang, Jing Cao(*)(共通讯),Weidong Zang(*). MiR-30b Attenuates Neuropathic Pain by RegulatingVoltage-Gated Sodium Channel Nav1.3 in Rats. Frontiers in MolecularNeuroscience (IF=5. 076)，2017 May 5;10:126

  9. 11.   Cao, Jing(#)，Wang,Po-Kai，Tiwari, Vinod，Liang, Lingli，Lutz,Brianna Marie，Shieh, Kun-Ruey，Zang,Wei-Dong，Kaufman, Andrew G，Bekker,Alex，Gao, Xiao-Qun，Tao, Yuan-Xiang(*)，Short-termpre- and post-operative stress prolongs incision-induced pain hypersensitivitywithout changing basal pain perception.，Molecular Pain (IF= 3.205)，2015，11（1）：73。

  10. 12.   Wang, Po-Kai(#)，Cao, Jing (#)(共一) ，Wang,Hongzhen，Liang, Lingli，Zhang,Jun，Lutz, Brianna Marie，Shieh, Kun-Ruey，Bekker,Alex，Tao, Yuan-Xiang(*)，Short-Term Sleep Disturbance-InducedStress Does not Affect Basal Pain Perception, but Does Delay Postsurgical PainRecovery. Journal of Pain  (IF= 4.859 )，2015，16（11）：1186-1199。

  11. 13.   Cao Jing(#)，LiZhihua，Zhang Zhenhua，Ren Xiuhua，ZhaoQingzan，Shao Jinping，Li Ming，WangJiannan，Huang Puchao，Zang Weidong(*)，Intrathecalinjection of fluorocitric acid inhibits the activation of glial cells causingreduced mirror pain in rats，BMC Anesthesiology (IF= 1.788)，2014，14：119。

  12. 14.   Cao Jing(#)，WangJiangshuan，Ren Xiuhua，ZangWeidong (*)，Spinal sample showing p-JNK andP38 associated with the pain signaling transduction of glial cell inneuropathic pain，Spinal Cord (IF= 1.936)，2014，11：188。

  13. 15.   Shao Jinping(#)，Cao Jing(#)(共一)，Ren  Xiuhua，Zang  Weidong . MicroRNA-30b regulates expressionof the sodium channel Nav1.7 in nerve injury-induced neuropathic pain in therat. Molecular Pain. (IF= 3.205).2016，12：1-13

  14. 16.   Weihua Cai(#)，Jing Cao(#)(共一)，Xiuhua Ren，Liang Qiao，XuemeiChen，Ming Li, Weidong Zang(*). shRNA Mediated Knockdown of Nav1.7 in RatDorsal Root GanglionAttenuates Pain Following Burn Injury, BMC Anesthesiolog(IF= 1.788). 2016 Aug 11;16(1):59-66

  15. 17.   Zhisong Li, Yuanyuan Mao, Lingli Liang, Shaogen Wu, Jingjing Yuan, KaiMo, Weihua Cai, Qingxiang Mao, Jing Cao, Alex Bekker, Wei Zhang,Yuan-Xiang Tao. The transcription factor C/EBPb in the dorsal root ganglioncontributes to peripheral nerve trauma–induced nociceptive hypersensitivity.Sci Signal (IF= 6.494). 2017 Jul 11;10(487)

  16. 18.   Li Zhisong(#)，Gu Xiyao，SunLinlin，Wu Shaogen，Liang Lingli，Cao Jing，LutzBrianna Marie，Bekker  Alex，Zhang Wei，TaoYuan-Xiang(*)，Dorsal root ganglion myeloidzinc finger protein 1 contributes to neuropathic pain after peripheral nervetrauma. Pain (IF=5.559)，2015，156（4）：711-721。

  17. 19.   Zhang J, Liang L, Miao X, Wu S, Cao J, Tao B, Mao Q, Mo K, Xiong M,Lutz  BM, Bekker A, Tao YX. Contributionof the Suppressor of Variegation 3-9 Homolog 1 in Dorsal Root Ganglia andSpinal Cord Dorsal Horn to Nerve Injury-induced Nociceptive Hypersensitivity.Anesthesiology(IF= 6.523) . 2016 Oct;125(4):765-78

 



荣誉与奖励

宝钢优秀教师  国家级 2019年

河南省优秀教师   省部级 2018年

教学优秀奖校级   2016-2017和2017-2018学年

河南省优秀解剖工作者 省级 2017年

“三育人”先进个人   校级   2017-2018学年