研究领域

1. 计算机辅助药物设计（CADD）新方法的设计和研究；

2. 基于STAT3蛋白靶点的抗肿瘤药物研究；

3. 基于活性天然化合物的合成方法研究和药物研究；

4.针对IL-6/JAK/STAT信号通路的药物研究。

论文与著作

1. 1.Wenying Yu, Chenglong Li, Wenda Zhang, Shanshan Li, Jia-yuh Lin, Keqin Yu, Mu Liu, Lei Yang, Jianguang Luo, Yijun Chen, Hongbin Sun, and Lingyi Kong*, Discovery of an orally selective inhibitor of signal transducer and activator of transcription 3 using advanced multiple ligand simultaneous docking, Journal of Medicinal Chemistry, 2017, 60, 2718-2731. (IF:6.3)

2. 2.Wenying Yu, Hui Xiao, Jiayuh Lin, Chenglong Li*, Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design, Journal of Medicinal Chemistry, 2013, 56, 4402−4412 (IF: 5.5)

3. 3.Wenda Zhang, Feiyan Liu, Chao Zhang, Jianguang Luo, Jun Luo, Wenying Yu**, and Lingyi Kong*, Near-Infrared Fluorescent Probe with Remarkable Large Stokes Shift and Favorable Water Solubility for Real-Time Tracking Leucine Aminopeptidase in Living Cells and In Vivo,Analytical Chemistry,2017, 89, 12319−12326. (IF: 6.2)

4. 4.Jianpeng Guo1, Wenying Yu1**, Guiping Cai, Wenda Zhang, Shanshan Li, Jiawen Zhu, Dongmei Song, Lingyi Kong*. Discovery of new benzensulfonamide derivatives as tripedal STAT3 inhibitors, European Journal of Medicinal Chemistry, 2018, 151, 752-764. (IF: 4.8)

5. 5.Wenda Zhang, Ting Ma, Shanshan Li, Yanwei Yang, Jianpeng Guo, Wenying Yu**, Lingyi Kong*, Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules, European Journal of Medicinal Chemistry, 2017, 125, 538-550. (IF: 4.8)

6. 6.Shanshan Li, Wenda Zhang, Yanwei Yang, Ting Ma, Jianpeng Guo, Shanshan Wang, Wenying Yu**, Lingyi Kong*, Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein, European Journal of Medicinal Chemistry, 2016, 124, 1006-1018. (IF: 4.5)

7. 7.Wenda Zhang, Jianpeng Guo, Shanshan Li, Ting Ma, Dingqiao Xu, Chao Han, Feiyan Liu, Wenying Yu**, Lingyi Kong*, Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy, Scientific Reports, 2017, 7:46352. (IF: 4.3)

8. 8.Wenying Yu, Chenglong Li*, Regioselective one-pot C-N coupling of substituted naphthoquinones: selective intramolecular ring fusion of sulfonamides, Tetrahedron, 2014, 70, 459-464. (IF: 2.6)

9. 9.Wenying Yu, Chenglong Li*, 4-Nitrophenyl N-(2-sulfamoylphenyl)-carbamate，Acta Crystallographica Section E, 2013, E69, o355

10. 10.余文颖, 张奕华*, 赖宜生, 接振旺, 张玉彬*, 彭司勋, 一氧化氮供体型双水杨酸酯衍生物的合成及降血糖活性, 中国药科大学学报, 2008, 39, 4, 301-305

11. 11.Chongqiang Zhao, Wenlong Wang, Wenying Yu, David Jou, Yina Wang, Haiyan Ma, Hui Xiao, Hua Qin, Cuntai Zhang, Jiagao Lu, Sheng Li, Chenglong Li, Jiayuh Lin, Li Lin*, A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration colon and liver cancer cells, Oncotarget, 2016 (IF: 5.2)

12. 12.Jin-Fang Xu, Hui-Jun Zhao, Xiao-Bing Wang, Zhong-Rui Li, Jun Luo, Ming-Hua Yang, Lei Yang, Wen-Ying Yu, He-Quan Yao, Jian-Guang Luo*, Ling-Yi Kong*, (±)-Melicolones A and B, rearranged prenylated acetophenone stereoisomers with an unusual 9-oxatricyclo[3.2.1.13,8]nonane core from the leaves of Melicope ptelefolia, Organic Letters, 2015, 17, 1, 146-149. (IF: 6.7)

13. 13.Yan Liu, Aiguo Liu, Zhenghu Xu, Wenying Yu, Hong Wang, Chenglong Li, Jiayuh Lin*,XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells, Apoptosis, 2011, 16, 5, 502-10. (IF: 4.8)

14. 14.Hui Xiao, Hemant Kumar Bid, David Jou, Xiaojuan Wu, Wenying Yu, Chenglong Li, Peter J. Houghton, Jiayuh Lin*, A Novel Small Molecular STAT3 Inhibitor, LY5, Inhibits Cell Viability, Cell Migration, and Angiogenesis in Medulloblastoma Cells, The Journal of Biological Chemistry, 2015, 290, 3418-3429. (IF: 4.3)

15. 15.Sai-Sai Xie, Xiaobing Wang, Neng Jiang, Wenying Yu, Kelvin D.G. Wang, Jin-Shuai Lan, Zhong-Rui Li, Ling-Yi Kong*, Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease, European Journal of Medicinal Chemistry, 2015, 95, 5, 153-165. (IF: 3.9)

16. 16.Aiguo Liu, Yan Liu, Zhenghu Xu, Wenying Yu, Hong Wang, Chenglong Li, Jiayuh Lin*, Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells, Cancer science, 2011, 102, 7, 1381-1387

17. 17.Yang Li, Xuliang Wang, Rong Fu, Wenying Yu, Xiaoli Wang, Yisheng Lai, Sixun Peng, Yihua Zhang*, Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents, Bioorganic & Medicinal Chemistry Letters, 2011, 21, 14, 4210-4214. (IF: 2.6)

18. 18.Zi-Chen Xu, Xiao-Bing Wang, Wen-Ying Yu, Sai-Sai Xie, Su-Yi Li, Ling-Yi Kong*, Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease, Bioorganic & Medicinal Chemistry Letters, 2014, 24, 10, 2368-237. (IF: 2.4)

荣誉与奖励

作为课题负责人主持了国家自然科学基金面上项目一项，江苏省自然科学基金优秀青年项目一项，国家自然科学基金青年项目一项，江苏省自然科学基金青年项目一项，留学回国人员择优资助项目一项等，经费共计逾百万元。作为主要参与人参加了国家自然科学基金重点项目等多项基金。2014年入选江苏省双创计划“双创博士”。2015年指导的大创项目被评为国家级优秀项目。