Education and Qualifications

2018.07-recent      School of Biotechnology, Jiangnan University, Professor

2014.06-recent      Jiangsu Engineering Technology Research Center, Deputy Director

2013.6-2018.06     School of Biotechnology, Jiangnan University, Associated Professor, Dean Assistant

2013.8-2014.10     Department of Chemistry and Chemical Biology, Harvard University, Postdoc

2009.7-2013.6      School of Biotechnology, Jiangnan University, Assistant Professor

2003.9-2009.6      Ph.D. Department of Fermentation Engineering, South China University of Technology.

1998.9-2002.7      B.A. School of Food and Biotechnology Engineering, South China University of Technology.

Research Field

Study on the evolution mechanism of microorganisms, enzymes and its application in fermentation engineering

Recent Publication

1.Gao L, Wu X, Zhu C, Jin Z, Wang W, Xia X*. Metabolic engineering to improve the biomanufacturing efficiency of acetic acid bacteria: advances and prospects[J]. Critical Reviews in Biotechnology, 2020, DOI: 10.1080/07388551.2020.1743231.

2.Yi Luo, Linghua Kong, Ruiqi Xue, Liangjie Duan, Xiaole Xia*. Bitterness in alcoholic beverages: The profiles of perception, constituents, and contributors. Trends in Food Science & Technology 96 (2020) 222-232. doi.org/10.1016/j.tifs.2019.12.026

3.Jianrong Wu, Xiaobei Zhan, Liming Liu, Xiaole Xia*, Bioproduction, purification, and application of polysialic acid. Applied Microbiology and Biotechnology, 2018, doi.org/10.1007/s00253-018-9336-3

4.Xiaole Xia, Yi Luo, Qingwen Zhang, Yang Huang. Mixed Strains Regulate Biogenic Amine Formation via Optimizing Decarboxylation and Transamination during Chinese Rice Wine Fermentation. J. Agric. Food Chem. 2018, 66, 25, 6348-6356  Cover Story

5.Xiaole Xia, Qingwen Zhang, Bin Zhang, Wuji Zhang, and Wu Wang. Insights into the Biogenic Amine Metabolic Landscape during Industrial Semidry Chinese Rice Wine Fermentation. J. Agric. Food Chem, 2016, 64 (39): 7385–7393

6.Qingtong Zhou#, Xiaole Xia#, Haojun Liang, Eugene Shakhnovich. Searching the sequence space for potent aptamers using SELEX in silico. Journal of Chemical Theory and Computation. 2015， 11(12), 5939-46.

7.Xiaole Xia, Xiaoming Zhu, Hailing Yang, et al. Enhancement of rice vinegar production by modified semi-continuous culture based on analysis of enzymatic kinetic. Eur Food Res Technol, 2015, 241(4): 479-485.

8.Xiao-Le Xia, Bo-Tao Fa, Shan Cong, Jingfang Wang, Kuocheng Chou. Insights into the Mutation-Induced Dysfunction of Arachidonic Acid Metabolism from Modeling of Human CYP2J2.  Current Drug Metabolism, 2014, 15(5): 502-513.

9.Xiao-Le Xia, Shan Cong, Xiao-Rong Weng, Jin-Hua Chen, Jing-Fang Wang, and Kuo-Chen Chou. Molecular Simulation to Investigate the Cofactor Specificity for Pichia stipitis Xylose Reductase. Medicinal Chemistry, 2013, 10, 921-924.

10.Wang Wu, Tang Leif, Xia Xiaole et al. Essentials in Biotechnology. Science Press (China). 2013.01

Funding grants

1.Study on molecular metabolism mechanism of biogenic amines in Chinese rice wine based on the evolutionary analysis of synthetic microbial ecosystem. National Natural Science Foundation of China, (No.31972064), 2020.1-2023.12

2.Demonstration study on the dynamic regulation and control of endogenous hazards in regional characteristic Chinese rice wine. National Key Research and Development Plan, (No. 2018YFC1604106), 2018.10-2021.12

3.Research on the relationship and regulation of food processing and food safety. National key research and development plan, (No.2017YFC1600401), 2017.7-2021.12.

4.Study on the robustness of lipase and its transformation. Project of Jiangsu natural science foundation, (No. BK20161129), 2016.8-2019.7.

5.Study on the physiological response mechanism of membrane transporter protein under the stress of bacillus bacillus. National Natural Science Foundation of China, (No. 31301540), 2014.1-2016.12.

6.Study on the prospective joint research project of industry-university-research in Jiangsu province. Key technology research on the efficient and safe brewing of functional yellow wine, (No. BY2013015-07), 2014.1-2015.12.

7.Study on the relationship between the structural effect of wheat germ lipase and its targeted transformation under ultrahigh pressure. 53 batches of Chinese postdoctoral support, (No. 2013M531273), 2013.6-2015.6.

8.The construction of "network" international oriented teaching system of biological engineering, Teaching reform project in Jiangsu province, 2015.7-2017.7.

Reward

1.Xiaole Xia, Zhiyong Zheng, Xiaobei Zhan, Bin Zhang, etc., First grade prize of Science and Technology Progress of China Light Industry Association. 2017

2.Xiaole Xia, Jiguo Yang, Jun Chen, etc., Second grade prize of Science and Technology Progress of China General Chamber of Commerce. 2016

3.Guocheng Du, Zhiming Rao, Jian Yin, Xiaole Xia, Minjie Gao, First grade prize of teaching achievement in Jiangsu province. 2017

4.Guocheng Du, Zheming Zhou, Xuemei Gao, Jian Yin, Xiaole Xia, Second grade prize of teaching achievement in Jiangsu province. 2013