Education and Qualifications

2020/01-present, National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Associate Professor

2014/10 -2015/10, Biotechnology Institute，University of Minnesota (Twist City), Visiting Scholar

2009/09- 2020/0, School of Biotechnology, Jiangnan University, Associate Professor

2004/09-200/07, School of Life Science and Biotechnology, Shanghai Jiao Tong University, PhD, Biomedical Engineering (Bioengineering).

2000/09-2004/07, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Bachelor Degree, Biotechnology

Research Field

Bioconversion, Bio Macro-molecule Interaction and Enzymatic Engineering.

Recent Publication

1. Guangming Fan, Yu Gu, Jiaojiao Zhang, Yu Xin*, Jun Shao*, Francesca Giampieri, Maurizio Battino*, Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy. International Journal of Molecular Sciences, 2019, 20, 6313. (IF 4.183)

2. Jun Shao, Yunbin Zhang, Guangming Fan, Yu Xin*, Yong Yao*, Transcriptome analysis identified a novel 3-LncRNA regulatory network of transthyretin attenuating glucose induced hRECs dysfunction in diabetic retinopathy. BMC Medical Genomics, 2019, 12: 134. (IF 2.568)

3. Jun Shao, Guangming Fan, Xiaowen Yin, Yu Gu, Xiaolu Wang, Yu Xin*, Yong Yao*, A novel transthyretin/STAT4/miR-223-3p/FBXW7 signaling pathway affects neovascularization in diabetic retinopathy. Molecular and Cellular Endocrinology, 2019, 498，110541. (IF 3.693)

4. Jun Shao, Xubin Pan, Xiaowen Yin, Guangming Fan, Chengye Tan, Yong Yao*, Yu Xin*, Chao Sun*, KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor. Journal of Cellular Physiology, 2019, 234, 17269-17279 (IF 4.522).

5. Yu Xin*, Mengyao Hao, Guangming Fan, Yao Zhang, Liang Zhang*，Soluble expression of Thermomicrobium roseum sarcosine oxidase and characterization of N-demethylation activity. Molecular Catalysis, 2019, 464, 48-56 (IF 4.211).

6. Mengyao Hao, Guangming Fan, Yao Zhang, Yu Xin*, Liang Zhang*，Preparation and characterization of copper-Brevibacterium cholesterol oxidase hybrid nanoflowers, International Journal of Biological Macromolecules, 2019, 126, 539-548 (IF 4.784).

7. Mengling Zheng, Mengyao Hao, Guangming Fan, Yao Zhang, Yu Xin*, Liang Zhang*, Preparation, reconstruction, and characterization of a predicted Thermomicrobium roseum sarcosine oxidase. Molecular Catalysis, 2018, 455, 132-142 (IF 4.211).

8. Yu Xin*, Mengyao Hao, Guangming Fan, Yao Zhang, Mengling Zheng, Liang Zhang*, Affinity adsorption of bovine hyaluronidase with ligands targeting to active site. Journal of Chromatography B, 2018, 1092,422-431 (IF 2.813).

9. Jun Shao, Ying Yin, Xiaowen Yina, Li Jia, Yu Xin*, Jian Zouc*, Yong Yao*, Transthyretin exerts pro-apoptotic effects in human retinal microvascular endothelial cells through a GRP78-dependent pathway in diabetic retinopathy. Cellular Physiology and Biochemistry，2017, 43, 788-800. (IF 5.50)

10. Yu Xin，Mengling Zheng，Qing Wang，Liushen Lu，Ling Zhang，Yanjun Tong，Wu Wang，Structural and catalytic alteration of sarcosine oxidase through reconstruction with coenzyme-like ligands，Journal of Molecular Catalysis B: Enzymatic，2016，133: S250–S258. (IF 2.269)

Funding grants

Natural Science Foundation of Jiangsu Province, The structural and functional modification at the key microdomains of flavoenzymes, BK20160053, 2016/07-2019/06;

Natural Science Foundation of China, The mechanism of the structural and functional modification of flavoenzymes based on coenzyme-like ligands, 21306064, 2014/01-2016/12;

Natural Science Foundation of Jiangsu Province, The mechanism of coenzyme-like ligands in the steady state and affinity purification of flavoenzymes, BK2012119, 2012/07-2015/06.

Reward

1. Yu Xin, Beizhan Chen, Wu Wang, Yongjun Zhu, Lanhua Liu, Yihui Yang, Zemin Wang, Minxi Yu, Science Technology Progress Award of Jiangxi Province, Third-Class, 2018, The production of aprotinin based on the High specific target separation technology.

2. Teaching Achievement Award of Jiangnan University, First-Class, 2011, Essentials of Biotechnology.