研究领域

中药活性成分及质量控制，专注中药化学成分快速解析、中药多成分标准化与经济化定量等重要关键性问题，①、创建了集高分辨质谱数据采集、筛选、鉴定与同分异构体区分于一体的中药化学成分解析新方法。②、创建了酶解绝对定量策略理论与方法，实现经济、“无标”或“少标”绝对定量中药类同物及体内代谢物。③、构建了“流动相补偿”技术，实现中药成分定量标准化。申请人近年来，主持完成国家自然科学青年科学基金1项、主持江西省自然科学基金青年基金重点项目1项、主持江西省卫生厅中医药科研计划1项、主持完成江西省自然科学基金面上项目1项、主持完成江西省青年科学基金1项、主持完成江西省卫生厅中医药科研计划1项。以第一作者或者通信作者在Analytical and Bioanalytical Chemistry、Journal of Pharmaceutical and Biomedical Analysis、Green chemistry等SCI杂志上发表系列研究论文17篇。

论文与著作

[1] Junmao Li^#, Quan Wen^#, Yulin Feng, Jing Zhang, Yun Luo^*, Ting Tan^*, Characterization of the multiple chemical components of Glechomae Herba using ultra high performance liquid chromatography coupled to quadrupole-time-of-flight tandem mass spectrometry with diagnostic ion filtering strategy, Journal of Separation Science, 2019, 42(7):1312-1322. 

[2] Yun Luo^#, Changjiangsheng Lai^#, Jing Zhang, Yulin Feng, Quan Wen^*, Ting Tan^*, Comprehensive metabolic profile of phenolic acids and flavonoids in Glechomae Herba using ultra-high-performance liquid chromatography coupled to quadrupole-time-of-flight tandem mass spectrometry with diagnostic ion filtering strategy, Journal of Pharmaceutical and Biomedical Analysis, 2019, 164: 615-629.

[3] Bo Ma, Shilin Yang, Junmao Li, Hui Ouyang, Mingzhen He , Yulin Feng^*, Ting Tan^*, A four-step filtering strategy based on ultra-high-performance liquid chromatography coupled to quadrupole-time-of-flight tandem mass spectrometry for comprehensive profiling the major chemical constituents of Akebiae Fructus, Rapid Communications in Mass Spectrometry, 2019, 33(18):1464-1474.

[4] Yun Luo^#, Quan Wen^#, Changjiangsheng Lai, Yulin Feng^*, Ting Tan^*, Characterization of polymeric phenolic acids and flavonoids in Clerodendranthi Spicati Herba using ultrahigh-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry with target and nontarget data mining strategy, Rapid Communications in Mass Spectrometry, 2019, 33(24):1884-1893.

[5] Jing Zhang^#, Quan Wen^#, Kai Qian, Yulin Feng, Yun Luo^*, Ting Tan^*, Metabolic profile of rosmarinic acid from Java tea (Orthosiphon stamineus) by ultra-high-performance liquid chromatography coupled to quadrupole-time-of-flight tandem mass spectrometry with a three-step data mining strategy, Biomedical Chromatography, 2019, 33(9):e4599.

[6] Yun Luo^#, Quan Wen^#, Shilin Yang, Yulin Feng^*, Ting Tan^*, Chemical composition and anti-complement activity of Glechomae Herba collected in different months, 2019, e4762.

[7] Ting Tan, Jing Zhang, Xu Xu, Wenping Huang, Yun Luo^*, Geographical discrimination of Glechomae Herba based on fifteen phenolic constituents determined by LC–MS/MS method combined with chemometric methods, Biomedical Chromatography, 2018, e4239.

[8] Ting Tan^#, Yun Luo^#, Chencong Zhong, Xu Xu, Yulin Feng^*, Comprehensive profiling and characterization of coumarins from roots, stems, leaves, branches, and seeds of Chimonanthus nitens Oliv. using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry combined with modified mass defect filter. Journal of Pharmaceutical and Biomedical Analysis, 2017, 141: 140-148.

[9] Ting Tan^#, Changjiangsheng Lai^#, Hui Ouyang, Mingzhen He, Yulin Feng^*, Ionic liquid-based ultrasound-assisted extraction and aqueous two-phase system for analysis of caffeoylquinic acids from Flos Lonicerae Japonicae, Journal of Pharmaceutical and Biomedical Analysis, 2016, 120: 134-141.

[10] Ting Tan^#, Changjiangsheng Lai^#, Suling Zeng, Ping Li^*, Ehu Liu^*, Comprehensive profiling and characterization of quassinoids from the seeds of Brucea javanica via segment and exposure strategy coupled with modified mass defect filter, Analytical and Bioanalytical Chemistry, 2016, 408: 527-533.

[11] Ting Tan^#, Changjiangsheng Lai^#, Suling Zeng, Ehu Liu^*, Ping Li^*, Enzymatic hydrolysis-based absolute quantification of triacylglycerols in plant oil by use of a single marker, Analytical and Bioanalytical Chemistry, 2014, 406: 4921-4929.

[12] Changjiangsheng Lai^#, Ting Tan^#, Suling Zeng, Linru Xu, Lianwen Qi^*, Ehu Liu^*, Ping Li^*, An enzymatic protocol for absolute quantification of analogues: application to specific protopanoxadiol-type ginsenosides, Green chemistry, 2015, 17: 2580-2586.

[13] Changjiangsheng Lai^#, Ting Tan^#, Sulin Zeng, Xin Dong, Ehu Liu^*, Ping Li^*, Relative quantification of multi-components in Panax notoginseng (Sanqi) by high-performance liquid chromatography with mass spectrometry using mobile phase compensation, Journal of Pharmaceutical and Biomedical Analysis, 2015, 102: 150-156.

[14] Wenping Huang^#, Ting Tan^#, Zhifeng Li, Hui Ouyang, Xu Xu, Bin Zhou^*, Yulin Feng^*, Structural characterization and discrimination of Chimonanthus nitens Oliv. leaf from different geographical origins based on multiple chromatographic analysis combined with chemometric methods, Journal of Pharmaceutical and Biomedical Analysis, 2018, 154: 236-244.

[15] Changjiangsheng Lai^#, Ting Tan^#, Sulin Zeng, Lianwen Qi, Xinguang Liu, Xin Dong, Ping Li^*, Ehu Liu^*, An integrated high resolution mass spectrometric data acquisition method for rapid screening of saponins in Panax notoginseng (Sanqi), Journal of Pharmaceutical and Biomedical Analysis, 2015, 109: 184-191.

[16] Yanzhi Zhan^#, Ting Tan^#, Kai Qian, Shilin Yang, Yulin Feng^*, Quan Wen^*, Quassinoids from seeds of Brucea Javanica and their anticomplement activities, Natural Product Research, 2019, 1-8.

[17] Xu Xu^#, Ting, Tan^# , Jing Zhang, ZhiFeng Li, ShiLin Yang, Quan Wen^*, Yulin Feng^*, Isolation of chemical constituents with anti-inflammatory activity from Reineckia carnea herbs, Journal of Asian Natural Products Research, 2019, 1-13.