余细勇
  • 单位：广州医科大学   药学院
  • 职称：教授
  • 职位：院长
  • 性别：男
  • 社会职务：
  • 微博：

研究领域

分子临床药理学和分子心血管病学



论文与著作

  1. 1. Huang W, Fen YL, Liang JL, Yu H, Jiang L, Paul C, Yu XY*, Wang Y*. miR-128 Functions as a Critical Regulator of Cardiomyocyte Proliferation and Cardiac Regeneration. Nat Commun.2017; accepted.

  2. 1.Jiang XY, Feng YL, Ye LT, Li XH, Feng J, Zhang MZ, Shelat HS, Wassler M, Li Y, Geng YJ,Yu XY(*). Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation. Stem Cell Reports. 2017; 8:290-304.

  3. 2.Shao LB, Zhang Y, Lan BB, WangJJ, Zhang ZW, Zhang LL, Xiao PL, Meng QY, Geng YJ, Yu XY(*), Li Y(*). MiRNA-sequence indicates that mesenchymal stem cells and exosomes have similar mechanism to enhance cardiac repair. BioMed Research International. 2017; 4150705. doi: 10.1155/2017/4150705

  4. 3.Li Y, Song YH, Liu B, Yu XY(*). The potential application and challenge of powerful CRISPR/Cas9 system in cardiovascular research. Int J Cardiol. 2017; 227:191-193.

  5. 4.Shen CC#, Zhou J#, Wang XX#, Yu XY#, Liang C, Liu B, Pan XB, Zhao Q, Song JL, Wang JJ, Bao MY, Wu CF, Li Y, Song YH*. Angiotensin-II-induced muscle wasting is mediated by 25-hydroxycholesterol via GSK3β signaling pathway. EBioMedicine. 2017; 16:238-250.

  6. 5.Liang J, Huang W, Cai W, Wang L, Guo L, Paul C, Yu XY(*), Wang Y(*). Inhibition of MicroRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells. Stem Cells. 2017; 35(2):337-350.

  7. 6.Xiao J, Pan Y, Li XH, Yang XY, Feng YL, Tan HH, Jiang L, Feng J, Yu XY(*). Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4. Cell Death Dis. 2016, 7(6):e2277. doi: 10.1038/cddis.2016.181.

  8. 7.Li Y(*), Song YH, Yu XY(*). Regarding article, "miR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis". Circulation. 2016,133(24):e713. doi: 10.1161/CIRCULATIONAHA.116.022001.

  9. 8.Yang H，Kuang SJ，Rao F，Xue YM，Liu XY，Shan ZX，Li XH，Zhu JN，Zhou ZL，Zhang XJ，Lin QX，Yu XY(*)，Deng CY(*).  Species-specific differences in the role of L-type Ca2+ channels in the regulation of coronary arterial smooth muscle contraction. Naunyn-Schmiedeberg's Arch Pharmacol. 2016, 389(2): 151-157.

  10. 9.Liu XY，Liu FC，Deng CY，Zhang MZ，Yang M，Xiao DZ，Lin QX，Cai ST，Kuang SJ，Chen J，Chen SX，Zhu JN，Yang H，Rao F，Fu YH，Yu XY(*). Left ventricular deformation associated with cardiomyocyte Ca(2+) transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats. BMC Cardiovasc Disord. 2016, 16(41): 1-12.

  11. 10.Li XH ，Li QQ，Jiang L，Deng C，Liu Z，Fu Y，Zhang M，Tan H，Feng Y，Shan Z，Wang J(*)，Yu XY(*). Generation of functional human cardiac progenitor cells by high-efficiency protein transduction. Stem Cells Transl Med. 2015，4(12)：1415-1424.

  12. 11.Yao Q ，Song R，Ao L，Zhan Q，Cleveland JC Jr，Fullerton DA，Yu XY(*)，Meng X(*). Over-expression of neurotrophin 3 in human aorticvalves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochim Biophys Acta.  2015，1852（9）：1940-1949.

  13. 12.Li Y，Shen ZY，Yu XY.  Transportof microRNAs via exosomes. Nat Rev Cardiol. 2015, 12(4): 198.  doi: 10.1038/nrcardio.2014.207-c1.

  14. 13.Wang XP，Zheng ZJ，He GD，Mai LP，Zhou ZL，Zhong SL，Lin QX，Shan ZX，Deng CY，Yang M，Yu XY(*).  Rapid determination of fenoldopam in human plasma by UPLC–MS/MS for pharmacokinetic analysis in patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2015，818-819（1）：78-82.

  15. 14.Feng Y，Huang W，Meng W，Jegga AG，Wang Y，Cai W，Kim HW，Wen Z，Rao F，Modi RM，Yu XY(*)，Ashraf M(*). Heat shock improves sca-1+ stem cells survival and directs ischemic cardiomyocytes towards a prosurvival phenotype via exosomal transfer: a critical role forHSF1/miR-34a/HSP70 pathway. Stem Cells. 2014，32：462-472.

  16. 15.Wang XP ，Zhou ZL，Yang M，Mai LP，Zheng ZJ，He GD，Wu YH，Lin QX，Shan ZX，Yu XY(*). Population pharmacokinetics and safety of eptifibatide in healthy Chinese volunteers and simulations on the dose regimens approved for a Western population. Int J Clin Pharmacol Ther. 2015，53（8）：658-666.

  17. 16.Huang W，Xiao DZ，Wang Y，Shan ZX，Liu XY，Lin QX，Yang M，Zhuang J，Li Y，Yu XY(*). Fn14 promotes differentiation of human mesenchymal stem cells into heart valvular interstitial cells by phenotypic characterization. J Cell Physiol. 2014，229（5）：580-587.

  18. 17.Deng CY，Yang H，Kuang SJ，Rao F，Xue YM，Zhou ZL，Liu XY，Shan ZX，Li XH，Lin QX，Wu SL，Yu XY(*). Upregulation of 5-hydroxytryptamine receptor signaling in coronary arteries after organ culture. PLoS One. 2014，9（9）：e107128.

  19. 18.Feng Y，Huang W，Wani M，Yu XY(*)，Ashraf M(*). Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One. 2014，9（2）：e88685.

  20. 19.Li Y(*)，Yu XY(*).  Regarding article, "Ten-eleven translocation-2(TET2) is a master regulator of smooth muscle cell plasticity".  Circulation. 2014，130（8）：e71. doi: 10.1161/CIRCULATIONAHA.113.007078.

  21. 20.Yu XY(*)，Geng YJ，Lei HP，Lin QX，Yuan J，Li Y(*). IGF-1 prevents high glucose-induced cell cycle arrest in cardiomyocytes via beta-catenin pathway. Int J Cardiol. 2013，168（3）：2869-2870.



荣誉与奖励

获广东省医药卫生科技进步奖5项（其中一等奖1项、二等奖1项、三等奖3项）,广东省科学技术奖一等奖1项、二等奖3项。