研究领域

1.智能给药；2.药物治疗肿瘤耐药性的机制研究；3.中药六类新药的开发

论文与著作

1. 第一作者论文

① Yi Zhou^#, Huaying Wen^#, Liang Gu, Jijun Fu, Jiayi Guo, Lingran Du, Xiaoqin Zhou, Xiyong Yu, Yugang Huang*, He Wang*. Aminoglucose-Functionalized and Redox-Responsive Polymer Nanomicelles for Overcoming Chemoresistance in Lung Cancer Cells. Journal of Nanobiotechnology, 11, 28 ;15(1) , 2017 (IF=5.29, 生物工程技术二区)

②Junwei Huang^#, Yi Zhou^#, Gregory S Thomas^#, Zhimin Gu, Ye Yang, Hongwei Xu, Guido Tricot, Fenghuang Zhang*. NEDD8 inhibition overcomes CKS1B induced drug resistance by upregulation of p21 in multiple myeloma cancer. Clinical Cancer Research, 21: 5532-42, 2015 (IF=10.32，肿瘤一区)

③ Yi Zhou, He Wang, Chengxi Wang, YongNan Jiang, Wenfen Lu, Shuifang Chen, Jianbing Zhao, Le Lai, Yuan Ping, Jianhai Chen*. Receptor–mediated, tumor-targeted gene delivery using folate-terminated polyrotaxanes. Mol. Pharmaceutics, 9, 1067-1076, 2012 (IF=4.56, 药学二区)

④ Yi Zhou^#, Jian-hai Chen^#，He Wang, Jian-ye Zhang, Cheng-xi Wang, Yi-wen Tao, Guo-dong Zheng, Hong-yan Xie, Yi Zhou*. Synthesis and characterization of folate-poly(ethylene glycol) chitosan graft-polyethylenimine as a non-viral carrier for tumor-targeted gene delivery. African Journal of Biotechnology, 4: 6120-6129. 2011 (IF=0.6)

⑤ Yi Zhou^#, He Wang, Lei Liang, Wenchan Zhao, Yan Chen, Hongzhu Deng*. Total alkaloid of Sophora Alopecuroides increases the expression of CD4+CD25+ Tregs and IL-10 in rats of experimental colitis. American Journal of Chinese Medicine, 38(2): 251-263. 2010 (IF=3.12)

2. 通讯作者论文

①Yazhong Ge^#, Qing Gao, Fengjiao Yan, Xiaona Zhang, Yurong Liu, Yi Zhou*.Su Yang Decoction Induces Human Colon Carcinoma Cell Apoptosis by Activating Caspases. Oncology letters, 17: 422-431, 2019

②Yuemin Wang^#, Xiaomei Chen, Dahua He, Yi Zhou,* and Linghao Qin^#,*. Surface-Modified Nanoerythrocyte Loading DOX for Targeted Liver Cancer Chemotherapy, Mol. Pharmaceutics 2018, 15, 5728−5740 (IF=4.56, 药学二区)

③He Wang^#, Mingna Sun^#, Jiayi Guo^#, Lei Ma, Hui Jiang, Liang Gu, Huaying Wen, Siyan Liao, Jingqi Chen, Bohang Zeng, Yongmei Li, Yueshan Li, Xiyong Yu, Yinghong Feng*, Yi Zhou*. 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways. Biochemical Pharmacology, 7, 135-145, 2017 (IF=4.23, 药学二区)

④He Wang^#, Shu Yang^#, Hong Zhou^#, Mingna Sun, Lingran Du, Minyan Wei, Meixia Luo, Jingzhu Huang, Hongzhu Deng, Yinghong Feng, Jun Huang, Yi Zhou*. Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms. Journal of Hematology & Oncology, 8:26, 2015. (IF=7.33，肿瘤二区)

⑤He Wang^#, Henghui Yin^#, Fengjiao Yan, Mingna Sun, Lingran Du, Wei Peng, Qiuli Li , Yinghong Feng, Yi Zhou*. Folate-mediated mitochondrial targeting with doxorubicin polyrotaxane nanoparticles overcomes multidrug resistance. Oncotarget, 6, 2827-42, 2015. (IF=5.12，肿瘤二区)

⑥He Wang^#, Hong Zhou^#, Cheng-Xi Wang, Yue-Shan Li, Hong-Yan Xie, Jian-Dong Luo, Yi Zhou*. Paeoniflorin inhibits growth of human colorectal carcinoma HT 29 cells in vitro and in vivo. Food and Chemical Toxicology, 50, 1560–1567, 2012. (IF=3.97，毒理二区)

荣誉与奖励

广州医科大学优秀教师；广州医科大学高水平建设培育项目骨干；获教育部教学软件评比三等奖1项