研究领域

主要从事神经变性疾病的机制研究，特别是帕金森病。实验室以细胞、果蝇和小鼠为模型，重点研究代谢和细胞器在帕金森病发病过程中的功能变化。

论文与著作

1. Zhang Z., Hartmann H., Do V.M., Abramowski D., Sturchler-Pierrat C., Staufenbiel M., Sommer B., van de Wetering M., Clevers H., Saftig P., De Strooper B., He X., Yankner B.A., Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature, 395 (6703)(1998):698-702.

2. Zhang Z., Nadeau P., Song W., Donoviel D., Yuan M., Bernstein A., Yankner B.A., Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol, 2 (7)(2000):463-5.

3. Tang B., Xiong H., Sun P., Zhang Y., Wang D., Hu Z., Zhu Z., Ma H., Pan Q., Xia J.H., Xia K., Zhang Z., Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. Hum Mol Genet, 15 (11)(2006):1816-25.

4. Wang D., Qian L., Xiong H., Liu J., Neckameyer W.S., Oldham S., Xia K., Wang J., Bodmer R., Zhang Z., Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A, 103 (36)(2006):13520-5.

5. Xiong H., Wang D., Chen L., Choo Y.S., Ma H., Tang C., Xia K., Jiang W., Ronai Z., Zhuang X., Zhang Z., Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest, 119 (3)(2009):650-60.

6. Tan J., Zhang T., Jiang L., Chi J., Hu D., Pan Q., Wang D., Zhang Z., Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein. J Biol Chem, 286 (34)(2011):29654-62.

7. Park G., Tan J., Garcia G., Kang Y., Salvesen G., Zhang Z., Regulation of Histone Acetylation by Autophagy in Parkinson Disease. J Biol Chem, 291 (7)(2016):3531-40.

8. Zhang T., Xue L., Li L., Tang C., Wan Z., Wang R., Tan J., Tan Y., Han H., Tian R., Billiar T.R., Tao W.A., Zhang Z., BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy. J Biol Chem, 291 (41)(2016):21616-21629.

9. Zhang L., Deng J., Pan Q., Zhan Y., Fan J.B., Zhang K., Zhang Z., Targeted methylation sequencing reveals dysregulated Wnt signaling in Parkinson disease. J Genet Genomics, 43 (10)(2016):587-592.

10. Wang R., Tan J., Chen T., Han H., Tian R., Tan Y., Wu Y., Cui J., Chen F., Li J., Lv L., Guan X., Shang S., Lu J., Zhang Z., ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. J Cell Biol, 218 (1)(2019):267-284.

11. Wan Z., Peng X., Ma L., Tian Q., Wu S., Li J., Ling J., Lv W., Ding B., Tan J., Zhang Z., Targeted Sequencing of Genomic Repeat Regions Detects Circulating Cell-free Echinococcus DNA. PLoS Negl Trop Dis, 2020 Mar 10;14(3):e0008147. doi: 10.1371/journal.pntd.0008147. eCollection 2020 Mar. PubMed PMID: 32155159; PubMed Central PMCID: PMC7083330.

12. Han H., Tan J, Wang R., Wan H., He Y., Yan X., Guo J., Gao Q., Li J., Shang S., Chen F., Tian R., Liu W., Liao L., Tang B., Zhang Z., PINK1 phosphorylates Drp1(S616) to regulate mitophagy-independent mitochondrial dynamics. EMBO Rep, 2020 Jun2:e48686. doi: 10.15252/embr.201948686. [Epub ahead of print] PubMed PMID:32484300.

13. Zhuohua Zhang, Beisha Tang, Jiada Li; Pathways to Cures; American Association for the Advancement of Science; 2013.

14.陈竺，傅松滨，张灼华，顾鸣敏；医学遗传学；人民卫生出版社；2015。

荣誉与奖励

1999年获国家自然科学基金杰出青年基金

2001年获美国V Scholar

2001年获教育部长江学者特聘教授

2007年获首届湖南省科技领军人才

2008年获中央组织部“国家千人计划”首批人选

2010年获国家自然科学奖二等奖

2013年获湖南省自然科学奖一等奖