一直从事食品安全快速检测技术、微流控芯片和生物传感器研究，并将开发食品中多种污染物同时检测的现场分析方法(POCT)作为主攻方向。开发了多种适配体标记的编码探针，用于对食品中多种抗生素、持久性有机污染物、β2抗体激动剂、雌激素的现场分析方法和小巧便携、易于操作的检测仪器。具体包括：

1）用于生物医学标志物和核酸检测的磁性生物传感器和微流控生物芯片研究；

2）复杂体系中有机污染物残留的高效分离和SPME-色谱-质谱分析研究；

3）高选择性的血脂蛋白快速分离和抗凝血材料研究。

论文与著作

[1]    Luan, Q., Gan, N*.,Cao, Y., & Li, T. Mimicking an Enzyme-Based Colorimetric Aptasensor forAntibiotic Residue Detection in Milk Combining Magnetic Loop-DNA Probes andCHA-Assisted Target Recycling Amplification. Journal of agricultural and foodchemistry, 2017,65(28),5731-5740.

[2]    Wang, Y., Gan, N*.,Zhou, Y., Li, T., Hu, F., Cao, Y., & Chen, Y. Novel label-free and high-throughputmicrochip electrophoresis platform for multiplex antibiotic residues detectionbased on aptamer probes and target catalyzed hairpin assembly for signalamplification. Biosensors and Bioelectronics, 2017,97, 100-106.

[3]    Luan, Q., Xi, Y., Gan,N*., Cao, Y., Li, T., & Chen, Y. A facile colorimetric aptamerassay for small molecule detection in food based on a magnetic single-strandedDNA binding protein-linked composite probe. Sensors and Actuators B: Chemical, 2017,239, 979-987.

[4]    Lv, F., Gan, N*.,Cao, Y*., Zhou, Y., Zuo, R., & Dong, Y. A molybdenum disulfide/reducedgraphene oxide fiber coating coupled with gas chromatography–mass spectrometryfor the saponification-headspace solid-phase microextraction of polychlorinatedbiphenyls in food. Journal of Chromatography A, 2017,1525, 42-50.

[5]    Feng, X.,Gan, N*., Zhang, H., Li, T., Cao, Y., Hu, F.,Jiang, Q.Ratiometric biosensor array for multiplexed detection of microRNAs based onelectrochemiluminescence coupled with cyclic voltammetry. Biosensorsand Bioelectronics, 2016,75,308-314.

[6]    Feng, X., Gan,N*., Zhang, H., Yan, Q., Li, T., Cao, Y.,Jiang, Q. A novel“dual-potential” electrochemiluminescence aptasensor array using CdS quantumdots and luminol-gold nanoparticles as labels for simultaneous detection ofmalachite green and chloramphenicol. Biosensors and Bioelectronics,2015, 74, 587-593

[7]    Wang, D., Gan,N*., Zhang, H., Li, T., Qiao, L., Cao, Y., Jiang, S. Simultaneouselectrochemical immunoassay using graphene–Au grafted recombinantapoferritin-encoded metallic labels as signal tags and dual-template magneticmolecular imprinted polymer as capture probes. Biosensorsand Bioelectronics, 2015,65,78-82.

[8]    Yan, Z., Gan,N*., Zhang, H., Wang, D., Qiao, L., Cao, Y., Hu, F. Asandwich-hybridization assay for simultaneous determination of HIV andtuberculosis DNA targets based on signal amplification by quantumdots-PowerVision™ polymer coding nanotracers. Biosensors and Bioelectronics, 2015,71, 207-213.

[9]    Miao, Y., Gan, N*.,Ren, H. X., Li, T., Cao, Y., Hu, F.,& Chen, Y. A triple-amplificationcolorimetric assay for antibiotics based on magnetic aptamer–enzymeco-immobilized platinum nanoprobes and exonuclease-assisted target recycling. Analyst, 2015, 140(22), 7663-7671.

[10]  Zhang, J., Gan, N*., Chen, S., Pan, M., Wu,D., & Cao, Y. β-cyclodextrin functionalized meso-/macroporous magnetictitanium dioxide adsorbent as extraction material combined with gaschromatography-mass spectrometry for the detection of chlorobenzenes in soilsamples. Journal of Chromatography A, 2015,1401, 24-32.

荣誉与奖励

“适应于重大疾病早期筛查和食品安全快检的磁性纳米生物芯片关键技术”获得2014年宁波市科技成果奖