研究领域

主要研究方向为生物无机化学

研究内容包括：

1）抗癌金属药物的设计、合成及机理研究；

2）金属人工核酸酶的设计及在核酸识别与切割中的应用；

3）生物体内重要阴、阳离子的识别与传感。

论文与著作

1. Zhanfen Chen,*Shuping Zhang, Jian Zhang, Zhenzhu Zhu, Enhanced anti-cancer efficacy tocancer cells by a novel monofunctional mononuclear platinum(II) complexcontaining a mixed S,N,S-donorligand. New Journal of Chemistry, 2017, 41, 6760-6768. RSC出版社，SCI源刊，IDSNO: CD2HJ, ISSN: 1144-0546 影响因子：3.269（作者序：1/4）

2. Zhanfen Chen,*Shuping Zhang, Zhenzhu Zhu, Yumin Zhang, A novel platinum(II) anticancercomplex of danysl bis(2-benzothiazolylmethyl)amine with dimethyl sulfoxide as aleaving group: synthesis, cytotoxicity, interaction with DNA and human serumalbumin. New Journal of Chemistry, 2017, 41, 6340-6348. RSC出版社，SCI源刊，IDSNO: CD2HJ, ISSN: 1144-0546 影响因子：3.269（作者序：1/4）

3. Zhanfen Chen,*Shuping Zhang, Jian Zhang, Affinity of a mononuclear monofunctionalanticancer Pt(II) complex to human serum albumin: a spectroscopic approach. Biometals, 2015, 28(6), 1031-1041.Springer出版社，SCI源刊，IDSNO: DB3XF, ISSN: 0966-0844  影响因子：2.503（作者序：1/3）

4. Zhanfen Chen,* ShupingZhang, Lei Shen, Zhenzhu Zhu, Jian Zhang, Fluorescence imaging of a newmonofunctional platinum(II) complex containing a thioflavin-T (ThT)-basedfluorophore. New Journal of Chemistry,2015, 39(3), 1592-1596. RSC出版社，SCI源刊，IDS NO: CD2HJ, ISSN: 1144-0546 影响因子：3.277 （作者序：1/5）

5. Zhanfen Chen,*Jian Zhang, Shuping Zhang, Oxidative DNA cleavage promoted by twophenolate-bridged binuclear copper(II) complexes. New Journal of Chemistry, 2015, 39(3), 1814-1821. RSC出版社，SCI源刊，IDS NO: CD2HJ, ISSN: 1144-0546 影响因子：3.277 （作者序：1/3）

6. Zhanfen Chen,* ShupingZhang, Jian Zhang, DNA binding, DNA cleavage and BSAinteraction of a bis-8-hydroxyquinoline copper(II) complex. Chemical Research, 2015,26(4), 404-416.（作者序：1/3）

7. Zhanfen Chen,*Yidan Ma, Luoguang Hua, Jian Zhang, Reactivities towards DNA and protein andcytotoxic activities of benzimidazole derived mononuclear cobalt(II) andnickel(II) complexes. Chinese Journal ofInorganic Chemistry, 2014,30(7), 1525-1534. SCI源刊，IDSNO: AL4VR, ISSN: 1001-4861. 影响因子：0.630（作者序：1/4）

8. Zhanfen Chen,* JianZhang, Pan Zeng, Shuping Zhang, Chuanmin Jin, Evaluation of DNA binding,protein interaction, and cytotoxic activity of a mononuclear copper(II)complex. Zeitschrift fur Anorganische undAllgemeine Chemie, 2014, 640(7),1506-1513.Wiley出版社，SCI源刊，IDS NO: AJ5RW, ISSN: 0044-2313. 影响因子：1.160（作者序：1/5）

9. Zhanfen Chen,* JianZhang, Changlin Liu, Study on the interaction between a water-soluble dinuclearnickel complex and bovine serum albumin by spectroscopic techniques. Biometals, 2013, 26(5), 827-838. Springer出版社，SCI源刊，IDS NO: DB3XF, ISSN: 0966-0844  影响因子：2.689（作者序：1/3）

10. Zhanfen Chen,* XiaoyongWang, Zijian Guo, DNA hydrolysis mediated by a tetranuclear zinc(II) complexwith 2,6-bis{[(2-hydroxybenzyl)(2-hydroxyetheyl)amino]methyl}-4-methylphenol. Chinese Journal of Inorganic Chemistry, 2011, 27(10), 1945-1951. SCI源刊，IDSNO: AL4VR, ISSN: 1001-4861. 影响因子：0.630（作者序：1/3）

11. 张健，张书萍，陈战芬,*酚氧桥联双核铜配合物的DNA结合性质和切割活性研究，第九届全国无机化学学术会议论文，2015，E-41.

12. 张书萍，张健，陈战芬,*双核单功能铂(II)配合物的DNA结合性质研究，第九届全国无机化学学术会议论文，2015，E-42.

13. 张书萍，程翠霞，陈战芬,* 光谱法研究新型单功能抗肿瘤铂配合物与人血清白蛋白的相互作用，2016年中西部地区无机化学学工学术研讨会会议论文，2016，205.

14. Yanyan Zhu, Zhanfen Chen, Zijian Guo, Yan Wang, Guangju Chen, Systematiccharacterization on electronic structures and spectra for a series of complexes,M(IDB)Cl₂ (M= Mn, Fe, Co, Ni, Cu and Zn): a theoretical study. Journal of Molecular Modeling 2009, 15, 469-479. SCI源刊 影响因子：1.871. (作者序：2/5)

15. Chuanmin Jin, Zhanfen Chen, Hongfei Mei, Xikui Shi, Ag(I) coordination polymers with flexible bis-imidazoleligands: 2D interwoven structure and wavy layer network based on silver-silverinteractions. J. Mol. Struct. 2009, 921, 58-62. Elsevier出版社, SCI源刊影响因子：1.486 (作者序：2/4)

16. Chuanmin Jin, Zhanfen Chen, Caiyuan Chen, JinghuaDong, Syntheses, crystal structures and properties oftwo cadmium coordination polymers containing bis(2-methylimidazol-1-yl) methane(2-mBIM) and bis(imidazol-1-yl)methane (BIM) ligands. J. Coord. Chem. 2009,62, 390-399. Elsevier出版社, SCI源刊 ISSN:0095-8972. 影响因子：0.87                                                          (作者序：2/4)

荣誉与奖励