Supplementary Reading Neptunlong

[Name and Structural Formula]

Product Name:Neptunlong

Formal Name:Oxaprozine

Major Ingredient:4,5-Diphenyl-2-oxazolepropionic acid

[Description]

White tablets, bitter in taste.

[Pharmacological Action]

Anti-inflammatory, analgesic and antipyretic.It is an inhibitor of restraining epoxidase that the biological synzyme of prostaglandin can be restrained.Only producing slight lesions in alimentary canal, it has long curative effect.

[Absorption, Distribution and Elimination]

Following single oral dose of 400 mg Neptunlong, the peak plasma concentrations are reached in about 3 to 4 hours.It leads to a 50 hours elimination half-life.The plasma concentrations become stable in 4 to 6 days after 10 days repeated administration of 400 mg daily with single or divided doses.Unrelated to dose, it is unaffected by meals.The total Neptunlong and the metabolites can be found in urine, and are excreted mainly by kidney.The main metabolites are glucuronolactone and hydroxylation.

[Indications]

Rheumatic arthritis, rheumatoid arthritis, tetanic spondylitis, periarthritis, cervical shoulder wrist syndrome, gout attack, injury and inflammation and pain after operation.

[Administration and Dosage]

400 mg daily, to be taken orally, single or divided dose after meals.The administration should be continued for over one week or follow the doctor’s advice.The stated dose is less than 600 mg daily.

[Side Effects]

Stomach-ache, no appetite, diarrhoea, constipation, nausea, thirst and stomatitis are the most frequently occurring symptoms in alimentary canal, along with vertigo, headache, drowsiness, tinnitus, tic and transient abnormality of liver function.

[Contraindications]

Individuals suffering from alimentary ulcer, serious hepatic and kidney diseases, who are hyperactive to other non-steroidal anti-inflammatory analgesic, patients suffering from blood disease, children, pregnant women and breast feeding women.

[Cautions]

(1)Suit the remedy to the case.The effects are in direct proportion to the time.

(2)The administration should be reduced or stopped if abnormality is found after long-term administration.

(3)Dosage together with anti-coagulant agent should be prudent.

[Package for Use]

200 mg per tablet, 10 tablets per carton.

[Storage]

Protect from light, and preserve in well-closed container.

[Expiry Date]

Three years.

NEW WORDS AND EXPRESSIONS

COMPREHENSION QUESTIONS

1.What is the pharmacological action of Neptonlong?

2.How long will the peak plasma concentration reach after a single dose of 400 mg Neptunlong? And its elimination half-life?

3.How is Neptunlong mainly excseted?

4.What are some of the diseases that Neptunlong is indicated to?

5.Can you tell the administration and dosage of Neptunlong?

6.What are the major side effects?

7.To whom is Neptunlong contraindicated?

8.Will you please say something about the cautions?