Overview

The nucleosome is the central organizing structure of the eukaryotic genome. It consists of DNA wrapped around histone proteins. Dr. Karolin Luger shares her discovery of the three-dimensional structure of the nucleosome using X-ray crystallography, which provided a deeper understanding of chromatin organization.

           The Pathway to DNA: The Double Helix Model

                                     Overview

In an interview with Ron Vale, Jim Watson tells us how his scientific interest moved from studying birds to DNA. He describes his journey to Cambridge, his collaboration with Francis Crick, the events leading to the elucidation of the double helix model for DNA, and his current passion of understanding cancer. His story illustrates why it is critical to identify and focus on important scientific problems.