药靶识别生物信息学工具

介绍药靶发现中常用的生物信息学工具：

课程内容：

1. 药物综合信息数据库——DrugBank

2. 疾病-基因-药物联通图——Cmap

授课目标

理解和掌握DrugBank和Cmap的原理和使用

课程资源：

1. 授课视频

请大家使用半个小时的时间进行Connectivity Map原理的讨论，再收看后边的视频。

2. 幻灯下载

3. 参考文献

《生物信息学理论与医学实践》李霞，人民卫生出版社，ISBN：978-7-117-16277-7

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037.

Law V, Knox C, Djoumbou Y, Jewison T, Guo AC, Liu Y, Maciejewski A, Arndt D, Wilson M, Neveu V, Tang A, Gabriel G, Ly C, Adamjee S, Dame ZT, Han B, Zhou Y, Wishart DS. DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res. 2014 Jan 1;42(1):D1091-7.

Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.

Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.

Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D668-72.

Lamb, J. The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 7, 54–60 (2007). https://doi.org/10.1038/nrc2044

Lamb, J. The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease[J]. Science, 2006, 313(5795):1929-1935.

4. 实验数据

无