个人介绍

研究领域

分子临床药理学和分子心血管病学

论文与著作

1. 1. Huang W, Fen YL, Liang JL, Yu H, Jiang L, Paul C, Yu XY*, Wang Y*. miR-128 Functions as a Critical Regulator of Cardiomyocyte Proliferation and Cardiac Regeneration. Nat Commun.2017; accepted.

2. 1.Jiang XY, Feng YL, Ye LT, Li XH, Feng J, Zhang MZ, Shelat HS, Wassler M, Li Y, Geng YJ,Yu XY(*). Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation. Stem Cell Reports. 2017; 8:290-304.

3. 2.Shao LB, Zhang Y, Lan BB, WangJJ, Zhang ZW, Zhang LL, Xiao PL, Meng QY, Geng YJ, Yu XY(*), Li Y(*). MiRNA-sequence indicates that mesenchymal stem cells and exosomes have similar mechanism to enhance cardiac repair. BioMed Research International. 2017; 4150705. doi: 10.1155/2017/4150705

4. 3.Li Y, Song YH, Liu B, Yu XY(*). The potential application and challenge of powerful CRISPR/Cas9 system in cardiovascular research. Int J Cardiol. 2017; 227:191-193.

5. 4.Shen CC^#, Zhou J^#, Wang XX^#, Yu XY^#, Liang C, Liu B, Pan XB, Zhao Q, Song JL, Wang JJ, Bao MY, Wu CF, Li Y, Song YH*. Angiotensin-II-induced muscle wasting is mediated by 25-hydroxycholesterol via GSK3β signaling pathway. EBioMedicine. 2017; 16:238-250.

6. 5.Liang J, Huang W, Cai W, Wang L, Guo L, Paul C, Yu XY(*), Wang Y(*). Inhibition of MicroRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells. Stem Cells. 2017; 35(2):337-350.

7. 6.Xiao J, Pan Y, Li XH, Yang XY, Feng YL, Tan HH, Jiang L, Feng J, Yu XY(*). Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4. Cell Death Dis. 2016, 7(6):e2277. doi: 10.1038/cddis.2016.181.

8. 7.Li Y(*), Song YH, Yu XY(*). Regarding article, "miR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis". Circulation. 2016,133(24):e713. doi: 10.1161/CIRCULATIONAHA.116.022001.

9. 8.Yang H，Kuang SJ，Rao F，Xue YM，Liu XY，Shan ZX，Li XH，Zhu JN，Zhou ZL，Zhang XJ，Lin QX，Yu XY(*)，Deng CY(*).  Species-specific differences in the role of L-type Ca2+ channels in the regulation of coronary arterial smooth muscle contraction. Naunyn-Schmiedeberg's Arch Pharmacol. 2016, 389(2): 151-157.

10. 9.Liu XY，Liu FC，Deng CY，Zhang MZ，Yang M，Xiao DZ，Lin QX，Cai ST，Kuang SJ，Chen J，Chen SX，Zhu JN，Yang H，Rao F，Fu YH，Yu XY(*). Left ventricular deformation associated with cardiomyocyte Ca(2+) transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats. BMC Cardiovasc Disord. 2016, 16(41): 1-12.

11. 10.Li XH ，Li QQ，Jiang L，Deng C，Liu Z，Fu Y，Zhang M，Tan H，Feng Y，Shan Z，Wang J(*)，Yu XY(*). Generation of functional human cardiac progenitor cells by high-efficiency protein transduction. Stem Cells Transl Med. 2015，4(12)：1415-1424.

12. 11.Yao Q ，Song R，Ao L，Zhan Q，Cleveland JC Jr，Fullerton DA，Yu XY(*)，Meng X(*). Over-expression of neurotrophin 3 in human aorticvalves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochim Biophys Acta.  2015，1852（9）：1940-1949.

13. 12.Li Y，Shen ZY，Yu XY.  Transportof microRNAs via exosomes. Nat Rev Cardiol. 2015, 12(4): 198.  doi: 10.1038/nrcardio.2014.207-c1.

14. 13.Wang XP，Zheng ZJ，He GD，Mai LP，Zhou ZL，Zhong SL，Lin QX，Shan ZX，Deng CY，Yang M，Yu XY(*).  Rapid determination of fenoldopam in human plasma by UPLC–MS/MS for pharmacokinetic analysis in patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2015，818-819（1）：78-82.

15. 14.Feng Y，Huang W，Meng W，Jegga AG，Wang Y，Cai W，Kim HW，Wen Z，Rao F，Modi RM，Yu XY(*)，Ashraf M(*). Heat shock improves sca-1+ stem cells survival and directs ischemic cardiomyocytes towards a prosurvival phenotype via exosomal transfer: a critical role forHSF1/miR-34a/HSP70 pathway. Stem Cells. 2014，32：462-472.

16. 15.Wang XP ，Zhou ZL，Yang M，Mai LP，Zheng ZJ，He GD，Wu YH，Lin QX，Shan ZX，Yu XY(*). Population pharmacokinetics and safety of eptifibatide in healthy Chinese volunteers and simulations on the dose regimens approved for a Western population. Int J Clin Pharmacol Ther. 2015，53（8）：658-666.

17. 16.Huang W，Xiao DZ，Wang Y，Shan ZX，Liu XY，Lin QX，Yang M，Zhuang J，Li Y，Yu XY(*). Fn14 promotes differentiation of human mesenchymal stem cells into heart valvular interstitial cells by phenotypic characterization. J Cell Physiol. 2014，229（5）：580-587.

18. 17.Deng CY，Yang H，Kuang SJ，Rao F，Xue YM，Zhou ZL，Liu XY，Shan ZX，Li XH，Lin QX，Wu SL，Yu XY(*). Upregulation of 5-hydroxytryptamine receptor signaling in coronary arteries after organ culture. PLoS One. 2014，9（9）：e107128.

19. 18.Feng Y，Huang W，Wani M，Yu XY(*)，Ashraf M(*). Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One. 2014，9（2）：e88685.

20. 19.Li Y(*)，Yu XY(*).  Regarding article, "Ten-eleven translocation-2(TET2) is a master regulator of smooth muscle cell plasticity".  Circulation. 2014，130（8）：e71. doi: 10.1161/CIRCULATIONAHA.113.007078.

21. 20.Yu XY(*)，Geng YJ，Lei HP，Lin QX，Yuan J，Li Y(*). IGF-1 prevents high glucose-induced cell cycle arrest in cardiomyocytes via beta-catenin pathway. Int J Cardiol. 2013，168（3）：2869-2870.

荣誉与奖励

获广东省医药卫生科技进步奖5项（其中一等奖1项、二等奖1项、三等奖3项）,广东省科学技术奖一等奖1项、二等奖3项。

个人介绍

研究领域

1.智能给药；2.药物治疗肿瘤耐药性的机制研究；3.中药六类新药的开发

论文与著作

1. 第一作者论文

① Yi Zhou^#, Huaying Wen^#, Liang Gu, Jijun Fu, Jiayi Guo, Lingran Du, Xiaoqin Zhou, Xiyong Yu, Yugang Huang*, He Wang*. Aminoglucose-Functionalized and Redox-Responsive Polymer Nanomicelles for Overcoming Chemoresistance in Lung Cancer Cells. Journal of Nanobiotechnology, 11, 28 ;15(1) , 2017 (IF=5.29, 生物工程技术二区)

②Junwei Huang^#, Yi Zhou^#, Gregory S Thomas^#, Zhimin Gu, Ye Yang, Hongwei Xu, Guido Tricot, Fenghuang Zhang*. NEDD8 inhibition overcomes CKS1B induced drug resistance by upregulation of p21 in multiple myeloma cancer. Clinical Cancer Research, 21: 5532-42, 2015 (IF=10.32，肿瘤一区)

③ Yi Zhou, He Wang, Chengxi Wang, YongNan Jiang, Wenfen Lu, Shuifang Chen, Jianbing Zhao, Le Lai, Yuan Ping, Jianhai Chen*. Receptor–mediated, tumor-targeted gene delivery using folate-terminated polyrotaxanes. Mol. Pharmaceutics, 9, 1067-1076, 2012 (IF=4.56, 药学二区)

④ Yi Zhou^#, Jian-hai Chen^#，He Wang, Jian-ye Zhang, Cheng-xi Wang, Yi-wen Tao, Guo-dong Zheng, Hong-yan Xie, Yi Zhou*. Synthesis and characterization of folate-poly(ethylene glycol) chitosan graft-polyethylenimine as a non-viral carrier for tumor-targeted gene delivery. African Journal of Biotechnology, 4: 6120-6129. 2011 (IF=0.6)

⑤ Yi Zhou^#, He Wang, Lei Liang, Wenchan Zhao, Yan Chen, Hongzhu Deng*. Total alkaloid of Sophora Alopecuroides increases the expression of CD4+CD25+ Tregs and IL-10 in rats of experimental colitis. American Journal of Chinese Medicine, 38(2): 251-263. 2010 (IF=3.12)

2. 通讯作者论文

①Yazhong Ge^#, Qing Gao, Fengjiao Yan, Xiaona Zhang, Yurong Liu, Yi Zhou*.Su Yang Decoction Induces Human Colon Carcinoma Cell Apoptosis by Activating Caspases. Oncology letters, 17: 422-431, 2019

②Yuemin Wang^#, Xiaomei Chen, Dahua He, Yi Zhou,* and Linghao Qin^#,*. Surface-Modified Nanoerythrocyte Loading DOX for Targeted Liver Cancer Chemotherapy, Mol. Pharmaceutics 2018, 15, 5728−5740 (IF=4.56, 药学二区)

③He Wang^#, Mingna Sun^#, Jiayi Guo^#, Lei Ma, Hui Jiang, Liang Gu, Huaying Wen, Siyan Liao, Jingqi Chen, Bohang Zeng, Yongmei Li, Yueshan Li, Xiyong Yu, Yinghong Feng*, Yi Zhou*. 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways. Biochemical Pharmacology, 7, 135-145, 2017 (IF=4.23, 药学二区)

④He Wang^#, Shu Yang^#, Hong Zhou^#, Mingna Sun, Lingran Du, Minyan Wei, Meixia Luo, Jingzhu Huang, Hongzhu Deng, Yinghong Feng, Jun Huang, Yi Zhou*. Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms. Journal of Hematology & Oncology, 8:26, 2015. (IF=7.33，肿瘤二区)

⑤He Wang^#, Henghui Yin^#, Fengjiao Yan, Mingna Sun, Lingran Du, Wei Peng, Qiuli Li , Yinghong Feng, Yi Zhou*. Folate-mediated mitochondrial targeting with doxorubicin polyrotaxane nanoparticles overcomes multidrug resistance. Oncotarget, 6, 2827-42, 2015. (IF=5.12，肿瘤二区)

⑥He Wang^#, Hong Zhou^#, Cheng-Xi Wang, Yue-Shan Li, Hong-Yan Xie, Jian-Dong Luo, Yi Zhou*. Paeoniflorin inhibits growth of human colorectal carcinoma HT 29 cells in vitro and in vivo. Food and Chemical Toxicology, 50, 1560–1567, 2012. (IF=3.97，毒理二区)

荣誉与奖励

广州医科大学优秀教师；广州医科大学高水平建设培育项目骨干；获教育部教学软件评比三等奖1项

个人介绍

研究领域

纳米靶向制剂的构建与评价

论文与著作

1.Minyan Wei, Xiucai Guo, Liuxiao Tu, Qi Zou, Qi Li, Chenyi Tang, Bao Chen, Yuehong Xu*, Chuanbin Wu*. Lactoferrin modified PEGylated liposomes loaded with doxorubicin for targeting delivery of hepatocellular carcinoma. Int J Nanomedicine, 2015, 10:5123–5137. (IF: 4.383)

2.Minyan Wei, Yuehong Xu*, Qi Zou, Liuxiao Tu, Chenyi Tang, Ting Xu, Lihe Deng, Chuanbin Wu*. Hepatocellular carcinoma targeting effect of PEGylated liposomes modified with lactoferrin. Eur J Pharm Sci, 2012, 46 (3):131-141. (IF: 3.291)

3.郑国栋, 杨秀娟, 曹颖欣, 胡坪君, 陈柏忠, 蔡轶, 韦敏燕*, HPLC法同时测定新会柑种子中7种成分, 中成药, 2019, 4, (8):1879-1883.

4.韦敏燕, 徐向东, 林伊君, 李旺盛, 蓝婷, 杨蕊梦, 唐文洁*, 超顺磁性四氧化三铁长循环脂质体的制备及表征, 中国医院药学杂志, 2019, 39, (16):1614-1619.

5.郑国栋，蓝婷，林伊君，杨蕊梦，唐文洁，周毅，杜玲然，韦敏燕*，微柱凝胶联合高校液相色谱法同时测定双载药脂质体中阿霉素与他莫昔芬的包封率，中国医院药学杂志，2017, 37(2)：108-111.

6.韦敏燕, 邹奇, 徐月红, 吴传斌. 乳铁蛋白修饰的长循环脂质体对肝癌细胞的体外靶向性评价. 药学学报, 2015, 50 (10):1272-1279.

7.韦敏燕, 张超, 陶移文, 李欣, 喻丽红, 张依, 李悦山（通讯作者）. 药剂学综合性实验教学体系的构建与实践. 广州医科大学学报, 2014, 42 (2): 60-61.

8.杨蕊梦，唐文洁，韦敏燕，赖胜圣，徐向东，梁思敏，魏新华，江新青*，双靶点磁性荧光双模态分子探针的制备及对乳腺癌体外靶向结合的可行性，中华放射学杂志，2016,05（1）：41-46.

9.Dongmei Meng, Haoyang Lu, Shanshan Huang, Minyan Wei, Pingtian Ding, Xianglin Xiao, Yuehong Xu*, Chuanbin Wu. Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration. Acta pharmaceutica Sinica. B, 2014, 4(1):74-78.

10.徐婷, 葛淑敏, 邓礼荷, 韦敏燕, 徐月红*，吴传斌. 土槿皮乙酸微乳的制备及体外经皮渗透性研究. 中草药, 2012, 43(4):683-689.

11.徐月红, 叶卉, 郭秀彩, 刘霞, 韦敏燕, 吴传斌*. 微透析联用反相高效液相色潽研究白芥子涂方皮肤药动学. 中草药, 2012, 43(2):336-340.

12.邓礼荷, 韦敏燕, 汤晨懿, 吴传斌, 徐月红*. 冻干工艺及保护剂对羟基喜树碱脂质体质量的影响. 中国医药工业杂志, 2012, 43 (1):30-34.

13.XU Ting, XU Yue-hong*, WEI Min-yan, DENG Li-he, WU Chuan-bin. In vitro study of transdermal penetration and iontophoresis of hepatitis B vacciness through rat skin. Acta Pharmaceutica sinica, 2011, 46 (6):713-719.

14.徐婷, 韦敏燕, 邓礼荷, 徐月红*, 吴传斌. 经皮免疫的研究进展. 中国药学杂志, 2010, 45 (24):1895-1899.

15.韦敏燕, 吴传斌, 徐月红*, 冯敏. 青霉素钠离子导入经皮吸收的研究. 中国医药工业杂志, 2010, 41 (7):518-521.

16.韦敏燕, 吴传斌, 叶卉, 徐月红*. 头孢唑林钠离子导入体内外透皮特性的研究. 中国药学杂志, 2009, 44 (20):1555-1559.

荣誉与奖励

2018年广州医科大学教师授课大赛三等奖

个人介绍

研究领域

论文与著作

(1) Mei Z,Yan P, Wang Y, Liu S, He F*. Knockdown of zinc transporter ZIP8 expressioninhibits neuroblastoma progression and metastasis in vitro. Mol Med Rep.2018;18(1):477-485. 

(2) Mei Z^#, Qiu J^#,Alcon S, Hashim J, Rotenberg A, Sun Y, Meehan WP 3rd, Mannix R*.Memantineimproves outcomes after repetitive traumatic brain injury. Behav Brain Res.2018;340:195-204

(3) Mei Z, Zheng P, Tan X, Wang Y, Situ B*.Huperzine A alleviates neuroinflammation, oxidative stress and improvescognitive function after repetitive traumatic brain injury.Metab Brain Dis.2017;32(6):1861-1869

(4) Mannix R*, Berkner J, Mei Z, Alcon S, Hashim J, Robinson S,Jantzie L, Meehan WP 3rd, Qiu J. Adolescent Mice Demonstrate a Distinct Patternof Injury after Repetitive Mild Traumatic Brain Injury. J Neurotrauma.2017;34(2):495-504

(5) Mei Z, Yan P, Tan X, Zheng S, Situ B*.Transcriptional Regulation of BACE1 by NFAT3 Leads to Enhanced AmyloidogenicProcessing. Neurochem Res, 2015;40(4):829-836

(6) 梅峥嵘，谭湘萍*，刘少志，黄汉辉. 葛根素减轻APP/PS1双转基因小鼠的认知障碍和tau蛋白过磷酸化. 中国中药杂志, 2016,41(17):3285-3289

(7) 梅峥嵘，司徒冰*，曾晓敏，王颖. 他克莫司对皮层神经元β-淀粉样蛋白生成及突触蛋白表达的影响. 中南药学, 2016, 14(11):1194-1197

(8) 梅峥嵘，张芳艳，吴仲洪，张仲林*. 隐丹参酮与多奈哌齐合用对β-淀粉样蛋白诱导SH-SY5Y细胞凋亡的保护作用. 重庆医学, 2014,43(10):1211-1213

(9) Mei Z, Yan P, Situ B, Mou Y*, Liu P*,Cryptotanshinione Inhibitsβ-Amyloid Aggregation andProtects Damage from β-Amyloid in SH-SY5Y Cells, NeurochemRes,2012,37(2):622-638

(10) 梅峥嵘，司徒冰，黄汉辉，严鹏科*, 灯盏花素对阿尔茨海默病模型大鼠学习记忆和抗氧化能力的影响，中国药学杂志，2012, 47(5):347-350

(11) Mei Z, Situ B, Tan X, Zheng S, Zhang F,Yan P, Liu P*. Cryptotanshinione upregulates alpha-secretase by activation PI3Kpathway in cortical neurons, Brain Res，2010,1348:165-173

荣誉与奖励